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<p>The multilayer nanoparticles (Multilayer NPs) were designed and characterized for the application to chemotherapy with enhanced therapeutic efficacy and reduced side effects. Multilayer NPs are composed of a doxorubicin (DOX)-loaded core and a multi-shell comprising Solutol, lecithin, and Pluronic. Multilayer NP structure was verified using a transmission electron microscope (TEM) and particle size analyzer. Biodistribution, antitumor efficacy, and tissue penetration efficiency were examined with tumor-bearing mice to understand the antitumor efficacy of Multilayer nanostructure. Finally, cardiotoxicity was evaluated to explain the reduced side effects of DOX.</p> Graphical abstract <p></p>

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Doxorubicin-loaded multilayer nanoparticles with enhanced antitumor efficacy and reduced cardiotoxicity

  • 期刊论文

  • 发表日期：

    2025年12月4日

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  • Ye Chan Kil,
  • Yeaji Kim,
  • Aryeong Choi,
  • Jae Yeon Kim,
  • Seong Jin Park,
  • Youngro Byun,
  • Yong Woo Jung,
  • Soon Hong Yuk

摘要

The multilayer nanoparticles (Multilayer NPs) were designed and characterized for the application to chemotherapy with enhanced therapeutic efficacy and reduced side effects. Multilayer NPs are composed of a doxorubicin (DOX)-loaded core and a multi-shell comprising Solutol, lecithin, and Pluronic. Multilayer NP structure was verified using a transmission electron microscope (TEM) and particle size analyzer. Biodistribution, antitumor efficacy, and tissue penetration efficiency were examined with tumor-bearing mice to understand the antitumor efficacy of Multilayer nanostructure. Finally, cardiotoxicity was evaluated to explain the reduced side effects of DOX.

Graphical abstract