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<p>Traditional wound dressing materials, such as gauge, cotton pads, adhesive bandages, etc., are non-occlusive, often incapable of handling high exudates, leading to drying out. Among various dressing materials available, foam dressing has shown better patient compliance and, most importantly, does not cause wound trauma. Synthetic polymers used for dressing foams possess some unfavourable health and environmental issues, when they interact with the human body, leading to hypersensitivity reactions, exposed particles can cause loss of consciousness and even blindness. These adverse outcomes can be averted by the use of natural polymers. Thus, this study focuses on the fabrication and characterization of foam dressing using natural polymers infused with graphene oxide (GO) as a self-healing nanomaterial. For the fabrication, the optimal concentration of polymers and GO have been selected using Quality by Design (QbD) approach. First of all, graphene oxide nanoparticles were prepared using the modified hummer’s method and were characterized using DLS, Raman spectroscopy, FESEM, FTIR, XRD, and TGA/DTA. The synthesis process involved the fabrication of foam dressing using combinations of various natural polymers having wound-healing property and the incorporation of GO into biocompatible polymer matrices. The best combination of polymers was decided based on preliminary characterization tests including absorption rate, fluid retention rate, water vapour transmission rate, and porosity test. Chitosan and sodium alginate combination was found to exhibit superior characteristics and was selected for optimization. It was further characterized to assess its morphological, mechanical, degradation, and antimicrobial studies. In conclusion, the optimized foam demonstrated superior properties, presenting a promising and safer alternative to synthetic polymer-based materials.</p> Graphical abstract <p>The fabrication and characterization of a self-healing foam dressing (FD) were carried out using natural polymers (chitosan, pectin, sodium alginate, and gelatin) infused with graphene oxide. Graphene oxide nanoparticles were synthesized using a modified Hummer’s method and characterized using DLS, Raman spectroscopy, FESEM, FTIR, XRD, and TGA/DTA. FDs were optimized using the Quality by Design (QbD) approach, ensuring superior absorption, fluid retention, water vapor transmission, and porosity. The optimized dressing exhibited excellent morphological, mechanical, degradation, and antimicrobial properties, making it a promising and biocompatible alternative to synthetic polymer-based wound dressings.</p> <p></p>

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Fabrication of graphene oxide infused natural polymers-based super absorptive self-healing foam dressing using quality by design approach

  • 期刊论文

  • 发表日期：

    2025年2月14日

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  • Kumar Anand,
  • Neelima Sharma

摘要

Traditional wound dressing materials, such as gauge, cotton pads, adhesive bandages, etc., are non-occlusive, often incapable of handling high exudates, leading to drying out. Among various dressing materials available, foam dressing has shown better patient compliance and, most importantly, does not cause wound trauma. Synthetic polymers used for dressing foams possess some unfavourable health and environmental issues, when they interact with the human body, leading to hypersensitivity reactions, exposed particles can cause loss of consciousness and even blindness. These adverse outcomes can be averted by the use of natural polymers. Thus, this study focuses on the fabrication and characterization of foam dressing using natural polymers infused with graphene oxide (GO) as a self-healing nanomaterial. For the fabrication, the optimal concentration of polymers and GO have been selected using Quality by Design (QbD) approach. First of all, graphene oxide nanoparticles were prepared using the modified hummer’s method and were characterized using DLS, Raman spectroscopy, FESEM, FTIR, XRD, and TGA/DTA. The synthesis process involved the fabrication of foam dressing using combinations of various natural polymers having wound-healing property and the incorporation of GO into biocompatible polymer matrices. The best combination of polymers was decided based on preliminary characterization tests including absorption rate, fluid retention rate, water vapour transmission rate, and porosity test. Chitosan and sodium alginate combination was found to exhibit superior characteristics and was selected for optimization. It was further characterized to assess its morphological, mechanical, degradation, and antimicrobial studies. In conclusion, the optimized foam demonstrated superior properties, presenting a promising and safer alternative to synthetic polymer-based materials.

Graphical abstract

The fabrication and characterization of a self-healing foam dressing (FD) were carried out using natural polymers (chitosan, pectin, sodium alginate, and gelatin) infused with graphene oxide. Graphene oxide nanoparticles were synthesized using a modified Hummer’s method and characterized using DLS, Raman spectroscopy, FESEM, FTIR, XRD, and TGA/DTA. FDs were optimized using the Quality by Design (QbD) approach, ensuring superior absorption, fluid retention, water vapor transmission, and porosity. The optimized dressing exhibited excellent morphological, mechanical, degradation, and antimicrobial properties, making it a promising and biocompatible alternative to synthetic polymer-based wound dressings.