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Background <p>Granulosa cell tumors (GCTs) of the ovary are rare sex cord–stromal neoplasms characterized by indolent growth and a propensity for late recurrence. Identification of reliable clinicopathological predictors of recurrence remains challenging.</p> Methods <p>This retrospective cohort study included 93 patients with ovarian granulosa cell tumors, with 137 histopathological specimens reviewed. Clinical, histomorphological, and treatment-related parameters were analyzed. Disease-free survival (DFS) was assessed using the Kaplan–Meier method and compared using the log-rank test.</p> Results <p>Recurrence was observed in 22% of patients, most commonly involving the pelvis and peritoneum. Capsular breach was significantly associated with reduced DFS (p = 0.03), and moderate nuclear atypia was significantly associated with recurrence (p = 0.002). The follow-up period extended up to 10&#xa0;years, with 5-year and 10-year DFS rates of 92% and 78%, respectively.</p> Conclusion <p>Capsular status and nuclear atypia are important predictors of recurrence in granulosa cell tumors. Long-term follow-up is essential for optimal patient management.</p>

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Clinicopathological Features and Survival Analysis of Ovarian Granulosa Cell Tumors from a Rural Tertiary Care Center

  • 期刊论文

  • 发表日期：

    2026年7月23日

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  • Arti Agarwal,
  • Manish Kumar,
  • Shikhar Chohan,
  • Roopak Aggarwal,
  • Sanjeev Kumar Singh,
  • Sufian Zaheer

摘要

Background

Granulosa cell tumors (GCTs) of the ovary are rare sex cord–stromal neoplasms characterized by indolent growth and a propensity for late recurrence. Identification of reliable clinicopathological predictors of recurrence remains challenging.

Methods

This retrospective cohort study included 93 patients with ovarian granulosa cell tumors, with 137 histopathological specimens reviewed. Clinical, histomorphological, and treatment-related parameters were analyzed. Disease-free survival (DFS) was assessed using the Kaplan–Meier method and compared using the log-rank test.

Results

Recurrence was observed in 22% of patients, most commonly involving the pelvis and peritoneum. Capsular breach was significantly associated with reduced DFS (p = 0.03), and moderate nuclear atypia was significantly associated with recurrence (p = 0.002). The follow-up period extended up to 10 years, with 5-year and 10-year DFS rates of 92% and 78%, respectively.

Conclusion

Capsular status and nuclear atypia are important predictors of recurrence in granulosa cell tumors. Long-term follow-up is essential for optimal patient management.