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Background <p>Pelvic lymph node metastasis (PLNM) is a key prognostic factor in early-stage cervical cancer. This study aims to evaluate the incidence of PLNM and to correlate clinical staging with pathological staging in early-stage cervical cancer.</p> Materials and Methods <p>This ambispective study included patients with early-stage cervical cancer (FIGO 2018 stages IA–IIA) who underwent radical hysterectomy with pelvic lymphadenectomy at IGIMS, Patna, between February 2020 and February 2025. Postoperative histopathological staging was used for correlation. Clinical and pathological variables were analyzed using univariate and multivariate models. Kaplan–Meier analysis was used for survival, and log-rank test was applied for statistical significance (<i>P</i> &lt; 0.05).</p> Results <p>Of 70 patients, 23 (32.8%) had pelvic lymph node metastases. The highest rates were observed in stages IIA1 (33.3%) and IB1 (30.76%). Squamous cell carcinoma accounted for 92.85% of cases (<i>P</i> = 0.0016), with 50% exhibiting lymph-vascular space invasion (LVSI), and 40% of these having PLNM. Multivariate analysis identified tumor grade (<i>P</i> = 0.0037), FIGO stage (<i>P</i> = 0.0043), and clinical stage (<i>P</i> = 0.0432) as significant predictors of survival. Five-year survival was 75% for stage IB and 62% for stage IIA patients (<i>P</i> = 0.0096). Median survival among high-grade tumors was 9&#xa0;months (95% CI: 3.56–33.56).</p> Conclusion <p>PLNM in early-stage cervical cancer is associated with advanced clinical stage, high tumor grade, and presence of LVSI. These patients are at increased risk of recurrence and poor survival and should be considered for adjuvant therapy.</p>

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Pelvic Lymph Node Involvement in Patients of Early-Stage Cervical Cancer: A Clinicopathological Correlation

  • 期刊论文

  • 发表日期：

    2026年3月9日

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  • Nikhat Praveen,
  • Sangeeta Pankaj,
  • Kavya Abhilashi,
  • Shivangi Shanker Shrivastava,
  • Rinu Kumari,
  • Priti Kumari,
  • Vijayanand Choudhary

摘要

Background

Pelvic lymph node metastasis (PLNM) is a key prognostic factor in early-stage cervical cancer. This study aims to evaluate the incidence of PLNM and to correlate clinical staging with pathological staging in early-stage cervical cancer.

Materials and Methods

This ambispective study included patients with early-stage cervical cancer (FIGO 2018 stages IA–IIA) who underwent radical hysterectomy with pelvic lymphadenectomy at IGIMS, Patna, between February 2020 and February 2025. Postoperative histopathological staging was used for correlation. Clinical and pathological variables were analyzed using univariate and multivariate models. Kaplan–Meier analysis was used for survival, and log-rank test was applied for statistical significance (P < 0.05).

Results

Of 70 patients, 23 (32.8%) had pelvic lymph node metastases. The highest rates were observed in stages IIA1 (33.3%) and IB1 (30.76%). Squamous cell carcinoma accounted for 92.85% of cases (P = 0.0016), with 50% exhibiting lymph-vascular space invasion (LVSI), and 40% of these having PLNM. Multivariate analysis identified tumor grade (P = 0.0037), FIGO stage (P = 0.0043), and clinical stage (P = 0.0432) as significant predictors of survival. Five-year survival was 75% for stage IB and 62% for stage IIA patients (P = 0.0096). Median survival among high-grade tumors was 9 months (95% CI: 3.56–33.56).

Conclusion

PLNM in early-stage cervical cancer is associated with advanced clinical stage, high tumor grade, and presence of LVSI. These patients are at increased risk of recurrence and poor survival and should be considered for adjuvant therapy.