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Introduction <p>Endometriosis is a chronic inflammatory disease that is estimated to affect up to 1 in 10 women of reproductive age group (Steinbuch et al. in Int J Mol Sci 25, 2024). Initially considered a benign disease, it is now thought that endometriosis, endometriomas specifically, are neoplastic conditions with the potential to become malignant.</p> Objective <p>Ovarian cancer, although rare, is more common in women with endometriosis, particularly endometrioid and clear-cell carcinoma types. Over the past few decades, various genetic mutations, microRNAs, and tumour microenvironmental factors have been identified (Chiaffarino et al. in Reprod Sci 31:1642–1650, 2024). Atypical endometriosis is being considered as a transition between endometriosis and ovarian malignancy.</p> Conclusion <p>The knowledge of malignant transformation of endometriosis and an understanding of potential risk factors is of paramount importance for determining patients at risk. Women that are known cases of severe endometriosis, large endometriomas, and atypical endometriosis, are an important population for targeted cancer screening and prevention studies.</p>

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Endometriosis Associated Ovarian Cancer: Case Reports

  • 期刊论文

  • 发表日期：

    2025年12月27日

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  • Sehal Shah,
  • Sarita Bhalerao,
  • Mehul Bhansali

摘要

Introduction

Endometriosis is a chronic inflammatory disease that is estimated to affect up to 1 in 10 women of reproductive age group (Steinbuch et al. in Int J Mol Sci 25, 2024). Initially considered a benign disease, it is now thought that endometriosis, endometriomas specifically, are neoplastic conditions with the potential to become malignant.

Objective

Ovarian cancer, although rare, is more common in women with endometriosis, particularly endometrioid and clear-cell carcinoma types. Over the past few decades, various genetic mutations, microRNAs, and tumour microenvironmental factors have been identified (Chiaffarino et al. in Reprod Sci 31:1642–1650, 2024). Atypical endometriosis is being considered as a transition between endometriosis and ovarian malignancy.

Conclusion

The knowledge of malignant transformation of endometriosis and an understanding of potential risk factors is of paramount importance for determining patients at risk. Women that are known cases of severe endometriosis, large endometriomas, and atypical endometriosis, are an important population for targeted cancer screening and prevention studies.