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Background <p>Posterior reversible encephalopathy syndrome (PRES) is a significant neurological complication associated with eclampsia, characterized by headache, seizures, and vasogenic edema predominantly in the parieto-occipital regions. This study aims to explore the clinical and radiological spectrum, management, and maternal outcomes of isolated PRES in eclampsia.</p> Purpose <p>Current study was conducted to understand the clinical and radiological nature of posterior reversible encephalopathy (PRES), when it happens alone without any other complications of pre-eclampsia and to know its prognosis and long-term neurological consequences.</p> Methods <p>A retrospective analysis was conducted on 366 eclampsia cases over 3 years at Mysore Medical College and Research Institute. Inclusion criteria focused on cases with isolated PRES, excluding those with additional complications such as AKI, HELLP, and DIC. Clinical data, neuroimaging results, and treatment outcomes were collected and analyzed.</p> Results <p>Out of 366 eclampsia cases, 110 (30%) were diagnosed with isolated PRES. The mean age of patients was 22 years, with a mean gestational age of 33 weeks. Typical eclampsia was observed in 88 cases, while atypical eclampsia was noted in 22 cases. The average blood pressure was significantly higher in typical cases (160/100 mmHg) compared to atypical cases (140/80 mmHg). MRI was required for 10 cases (9%) to confirm PRES diagnosis. No maternal mortality was reported, and six near-miss cases were identified. Long-term follow-up indicated no neurological deficits in patients with isolated PRES.</p> Conclusion <p>The study highlights that isolated PRES in eclampsia can have favorable maternal outcomes when managed appropriately. The findings suggest that timely diagnosis and treatment are crucial in preventing long-term neurological sequelae.</p>

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A Clinical and Radiological Spectrum of Isolated Posterior Reversible Encephalopathy Syndrome in Eclampsia

  • 期刊论文

  • 发表日期：

    2025年11月8日

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  • Sushma V. Dev,
  • Madhura K. P,
  • Sanoo S. Bhoomkar

摘要

Background

Posterior reversible encephalopathy syndrome (PRES) is a significant neurological complication associated with eclampsia, characterized by headache, seizures, and vasogenic edema predominantly in the parieto-occipital regions. This study aims to explore the clinical and radiological spectrum, management, and maternal outcomes of isolated PRES in eclampsia.

Purpose

Current study was conducted to understand the clinical and radiological nature of posterior reversible encephalopathy (PRES), when it happens alone without any other complications of pre-eclampsia and to know its prognosis and long-term neurological consequences.

Methods

A retrospective analysis was conducted on 366 eclampsia cases over 3 years at Mysore Medical College and Research Institute. Inclusion criteria focused on cases with isolated PRES, excluding those with additional complications such as AKI, HELLP, and DIC. Clinical data, neuroimaging results, and treatment outcomes were collected and analyzed.

Results

Out of 366 eclampsia cases, 110 (30%) were diagnosed with isolated PRES. The mean age of patients was 22 years, with a mean gestational age of 33 weeks. Typical eclampsia was observed in 88 cases, while atypical eclampsia was noted in 22 cases. The average blood pressure was significantly higher in typical cases (160/100 mmHg) compared to atypical cases (140/80 mmHg). MRI was required for 10 cases (9%) to confirm PRES diagnosis. No maternal mortality was reported, and six near-miss cases were identified. Long-term follow-up indicated no neurological deficits in patients with isolated PRES.

Conclusion

The study highlights that isolated PRES in eclampsia can have favorable maternal outcomes when managed appropriately. The findings suggest that timely diagnosis and treatment are crucial in preventing long-term neurological sequelae.