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<p>This review provides an in-depth exploration of organ-on-a-chip (OOC) technology with a particular focus on kidney-on-a-chip systems. It examines the core principles of OOC, including the variety of materials, microfluidic designs, and the potential applications in drug testing, disease modeling, and personalized medicine. The review delves into the unique challenges in developing OOC systems, including fabrication methods, cost, and the pressing need for standardization across platforms. Specific attention is given to kidney-on-a-chip technology, emphasizing the modeling of the glomerular filtration barrier (GFB)—a crucial element in kidney function. The GFB’s structure, comprising the fenestrated endothelium, basement membrane, and podocytes, is analyzed in the context of its role in filtration. While advancements in GFB modeling offer significant insights into renal disease mechanisms and drug toxicity testing, challenges remain, including achieving accurate GFB replication, sourcing high-quality human kidney cells, and optimizing culture conditions. The review concludes by highlighting the transformative potential of kidney-on-a-chip systems, while emphasizing the necessity for standardization and reproducibility to fully realize their biomedical applications.</p>

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Advances and Challenges in 3D Modelling of Organ-on-a-Chip Devices with a Focus on the Glomerular Basement Membrane (GBM) and Tubular Systems: A Critical Review

  • 期刊论文

  • 发表日期：

    2025年1月7日

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  • Jumanah Bahig,
  • Ahmed Shoker,
  • Huu Doan,
  • Katalin Szaszi,
  • Amira Abdelrasoul

摘要

This review provides an in-depth exploration of organ-on-a-chip (OOC) technology with a particular focus on kidney-on-a-chip systems. It examines the core principles of OOC, including the variety of materials, microfluidic designs, and the potential applications in drug testing, disease modeling, and personalized medicine. The review delves into the unique challenges in developing OOC systems, including fabrication methods, cost, and the pressing need for standardization across platforms. Specific attention is given to kidney-on-a-chip technology, emphasizing the modeling of the glomerular filtration barrier (GFB)—a crucial element in kidney function. The GFB’s structure, comprising the fenestrated endothelium, basement membrane, and podocytes, is analyzed in the context of its role in filtration. While advancements in GFB modeling offer significant insights into renal disease mechanisms and drug toxicity testing, challenges remain, including achieving accurate GFB replication, sourcing high-quality human kidney cells, and optimizing culture conditions. The review concludes by highlighting the transformative potential of kidney-on-a-chip systems, while emphasizing the necessity for standardization and reproducibility to fully realize their biomedical applications.