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<p>A gradual and complex neurological disease, dementia significantly impairs cognitive abilities. Oxidative stress and chronic inflammation are the two common factors behind this. In this study, the neuroprotective effects of a hydro-ethanolic extract of <i>Tecomella undulate</i> (TUHEE) were investigated against streptozotocin (STZ)-induced dementia in adult zebrafish. Further, in this study, 60 adult zebrafish (470–530&#xa0;mg) of approximately 3 months old were taken and divided into five groups (<i>n</i> = 12): Normal control—received normal saline, Negative control—received STZ (300&#xa0;mg/kg), Positive control—received Donepezil (DPZ) (3&#xa0;mg/kg), Test group 1—received TUHEE (200&#xa0;mg/kg), Test group 2—received TUHEE (500&#xa0;mg/kg). When adult zebrafish were exposed to STZ, their behaviour and biochemical parameters were significantly altered. When compared to the normal group, STZ-treated zebrafish showed a preference for the dark compartment in the light and dark test. Additionally, in the T-maze test, STZ-treated zebrafish spent more time in the unfavourable zone and had higher transfer latency (TL), and in the novel diving test, STZ-treated animals spent less time and made minimal entries to the top zone in the novel diving tank apparatus. Furthermore, TUHEE significantly decreased the cognitive dysfunction in the T-maze apparatus, light and dark test and novel diving test, rather than STZ treated group with a significant reduction in inflammatory, oxidative biomarkers &amp; AChE activity. The in vitro study on SHSY-5Y cells, in which it decreased the production of reactive oxygen species (ROS), concentration of IL-6, and Nuclear Factor Kappa-B (NF-κB) translocation, further confirmed the potential.</p>

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Exploring the neuroprotective potential of Tecomella undulata plant extract in dementia induced adult zebrafish through modulation of oxidative stress and inflammation biomarkers

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Bharti Verma,
  • Jayendra Kumar

摘要

A gradual and complex neurological disease, dementia significantly impairs cognitive abilities. Oxidative stress and chronic inflammation are the two common factors behind this. In this study, the neuroprotective effects of a hydro-ethanolic extract of Tecomella undulate (TUHEE) were investigated against streptozotocin (STZ)-induced dementia in adult zebrafish. Further, in this study, 60 adult zebrafish (470–530 mg) of approximately 3 months old were taken and divided into five groups (n = 12): Normal control—received normal saline, Negative control—received STZ (300 mg/kg), Positive control—received Donepezil (DPZ) (3 mg/kg), Test group 1—received TUHEE (200 mg/kg), Test group 2—received TUHEE (500 mg/kg). When adult zebrafish were exposed to STZ, their behaviour and biochemical parameters were significantly altered. When compared to the normal group, STZ-treated zebrafish showed a preference for the dark compartment in the light and dark test. Additionally, in the T-maze test, STZ-treated zebrafish spent more time in the unfavourable zone and had higher transfer latency (TL), and in the novel diving test, STZ-treated animals spent less time and made minimal entries to the top zone in the novel diving tank apparatus. Furthermore, TUHEE significantly decreased the cognitive dysfunction in the T-maze apparatus, light and dark test and novel diving test, rather than STZ treated group with a significant reduction in inflammatory, oxidative biomarkers & AChE activity. The in vitro study on SHSY-5Y cells, in which it decreased the production of reactive oxygen species (ROS), concentration of IL-6, and Nuclear Factor Kappa-B (NF-κB) translocation, further confirmed the potential.