Scholarlink

<p>Acarbose is an α-glucosidase inhibitor that helps lower blood sugar after meals by stopping complex carbohydrates from turning into simple sugars; however, its role other than α-glucosidase inhibition is not yet fully understood. In this study, we used bioinformatics to explore the molecular targets and mechanisms of acarbose in type 2 diabetes (T2D). We found one hundred and twenty-seven shared targets between proteins linked to acarbose and genes related to T2D. Analysis showed these targets are mainly involved in insulin signaling, glucose metabolism, PI3K/Akt pathway, and inflammation. Network analysis highlighted 10 important genes: AKT1, ALB, EGFR, ESR1, GSK3B, HSP90AA1, PPARG, STAT3, SRC, and TNF. Expression profiling showed these genes have different patterns in various tissues from diabetic samples. Molecular docking results indicated a binding affinity of acarbose with the key proteins, with EGFR showing the lowest binding energy of − 7.8&#xa0;kcal/mol. Molecular dynamics (MD) simulations confirmed that the acarbose-protein complexes, especially with EGFR, STAT3, PPARG, and HSP90AA1, are stable. Overall, these results provide a detailed information on how acarbose may act on multiple targets other than inhibiting α-glucosidase in T2D.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabetes

  • 期刊论文

  • 发表日期：

    2026年3月25日

查看全文
  • Sourbh Suren Garg,
  • Deepanshi Vijh,
  • Promila Gupta,
  • Jeena Gupta,
  • Md. Zubbair Malik

摘要

Acarbose is an α-glucosidase inhibitor that helps lower blood sugar after meals by stopping complex carbohydrates from turning into simple sugars; however, its role other than α-glucosidase inhibition is not yet fully understood. In this study, we used bioinformatics to explore the molecular targets and mechanisms of acarbose in type 2 diabetes (T2D). We found one hundred and twenty-seven shared targets between proteins linked to acarbose and genes related to T2D. Analysis showed these targets are mainly involved in insulin signaling, glucose metabolism, PI3K/Akt pathway, and inflammation. Network analysis highlighted 10 important genes: AKT1, ALB, EGFR, ESR1, GSK3B, HSP90AA1, PPARG, STAT3, SRC, and TNF. Expression profiling showed these genes have different patterns in various tissues from diabetic samples. Molecular docking results indicated a binding affinity of acarbose with the key proteins, with EGFR showing the lowest binding energy of − 7.8 kcal/mol. Molecular dynamics (MD) simulations confirmed that the acarbose-protein complexes, especially with EGFR, STAT3, PPARG, and HSP90AA1, are stable. Overall, these results provide a detailed information on how acarbose may act on multiple targets other than inhibiting α-glucosidase in T2D.