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<p>The present study aims to explore the biological and functional properties of melanin derived from fungus <i>Thermothelomyces hinnuleus</i> SP1. Fungal melanin had detrimental effect on the tested bacterial strains with a zone size ranging from 18 ± 1–35.67 ± 2.08&#xa0;mm and a minimal inhibitory concentration ranging from 0.97–1.95&#xa0;µg/ml respectively. It exhibited significant DPPH radical scavenging activity (27 ± 1.88–86 ± 2.56%), temperature-dependent superoxide dismutase activity (19.8 ± 3.45–87.82 ± 1.31%) and catalase-mimetic activity (59.48 ± 1.35%). Moreover, it showed biocompatibility (94.9 ± 3.18–98.83 ± 1.83% cell viability) with HaCaT cell lines, while it had a dose dependent anticancer effect on Hela, MCF and MDA-MB-231 cell lines with IC<sub>50</sub> values of 54 ± 1.7, 35 ± 1.5 and 60 ± 2&#xa0;µg/ml respectively. Fungal melanin also exhibited photoprotection property with a SPF values of 10.67. These findings indicate that the fungal melanin obtained from <i>Thermothelomyces hinnuleus</i> SP1 possesses significant biological properties including photoprotective, antimicrobial, antioxidant, anticancer and biocompatible activities. Such attributes underscore its potential as a multifunctional natural agent, particularly for applications in cosmetics and pharmaceuticals.</p>

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Exploring the Multifunctional Biological Properties of Melanin Derived from Thermothelomyces hinnuleus SP1 for Health, Cosmetic, and UV-Protective Uses

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Shalini Pandey,
  • Vineet Meshram,
  • Krishna Tamboli,
  • Ankit Rai,
  • Poonam Bansal,
  • Mahiti Gupta,
  • Gunjan Sharma,
  • Surbhi Goel,
  • Arunima Sur

摘要

The present study aims to explore the biological and functional properties of melanin derived from fungus Thermothelomyces hinnuleus SP1. Fungal melanin had detrimental effect on the tested bacterial strains with a zone size ranging from 18 ± 1–35.67 ± 2.08 mm and a minimal inhibitory concentration ranging from 0.97–1.95 µg/ml respectively. It exhibited significant DPPH radical scavenging activity (27 ± 1.88–86 ± 2.56%), temperature-dependent superoxide dismutase activity (19.8 ± 3.45–87.82 ± 1.31%) and catalase-mimetic activity (59.48 ± 1.35%). Moreover, it showed biocompatibility (94.9 ± 3.18–98.83 ± 1.83% cell viability) with HaCaT cell lines, while it had a dose dependent anticancer effect on Hela, MCF and MDA-MB-231 cell lines with IC50 values of 54 ± 1.7, 35 ± 1.5 and 60 ± 2 µg/ml respectively. Fungal melanin also exhibited photoprotection property with a SPF values of 10.67. These findings indicate that the fungal melanin obtained from Thermothelomyces hinnuleus SP1 possesses significant biological properties including photoprotective, antimicrobial, antioxidant, anticancer and biocompatible activities. Such attributes underscore its potential as a multifunctional natural agent, particularly for applications in cosmetics and pharmaceuticals.