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<p>This study evaluated the effect of Mogan large-leaf yellow tea (MG-LYT) on preventing obesity. It was found that cold-brewed yellow tea has stronger anti-obesity effects in high-fat diet (HFD)-induced obese mice than hot-brewed tea, due to its higher content of non-esterified catechins, as shown by metabolomic and high-performance liquid chromatography (HPLC) analysis. Notably, epigallocatechin (EGC), a key non-ester catechin, likely enhances pancreatic lipase inhibition through allosteric modulation, which explains the greater effectiveness of cold-brewed tea. Dietary supplementation with cold-brewed MG-LYT significantly reduced HFD-induced obesity and related metabolic disorders in mice, including hepatic steatosis, dyslipidemia, and adipose accumulation, while elevating fecal short-chain fatty acid (SCFA) levels and modulating gut microbiota composition. These findings suggest that cold-brewed yellow tea may be a beneficial daily beverage for preventing obesity, improving metabolic health, and regulating gut microbiota.</p>

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Cold-brewed yellow tea showed stronger inhibition on high-fat diet induced mice obesity than that hot brewed, due to higher non-ester catechins content based on metabolomic profile

  • 期刊论文

  • 发表日期：

    2025年9月2日

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  • Lianbao Zheng,
  • Yuanhang Yang,
  • Qun Ye,
  • Fang Wang,
  • Xiaohong Zhang,
  • Zhengyu Hou,
  • Chenghui Lu,
  • Baoming Tian,
  • Renjie Liu,
  • Tong Hu,
  • Weihong Zhong

摘要

This study evaluated the effect of Mogan large-leaf yellow tea (MG-LYT) on preventing obesity. It was found that cold-brewed yellow tea has stronger anti-obesity effects in high-fat diet (HFD)-induced obese mice than hot-brewed tea, due to its higher content of non-esterified catechins, as shown by metabolomic and high-performance liquid chromatography (HPLC) analysis. Notably, epigallocatechin (EGC), a key non-ester catechin, likely enhances pancreatic lipase inhibition through allosteric modulation, which explains the greater effectiveness of cold-brewed tea. Dietary supplementation with cold-brewed MG-LYT significantly reduced HFD-induced obesity and related metabolic disorders in mice, including hepatic steatosis, dyslipidemia, and adipose accumulation, while elevating fecal short-chain fatty acid (SCFA) levels and modulating gut microbiota composition. These findings suggest that cold-brewed yellow tea may be a beneficial daily beverage for preventing obesity, improving metabolic health, and regulating gut microbiota.