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<p>Tin chloride, a heavy metal compound, induces neurotoxicity and is associated with Parkinson’s disease (PD), a condition characterized by inflammation and oxidative stress. Curcumin, a polyphenolic compound, is widely recognized for its antioxidant and anti-inflammatory properties. This study examined the neuroprotective effects of nanocurcumin in a rat model of PD induced by tin (II) chloride. 20 Wistar rats were randomly assigned to four groups (<i>n</i> = 5/group): control, nanocurcumin (20&#xa0;mg/kg), tin chloride, and tin chloride + nanocurcumin. After 4&#xa0;weeks, brain tissues were analyzed histologically and for expression of inflammatory markers (IL-6, MCP-1, α-synuclein). Serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), calcium (Ca2⁺), and tin were also measured. Nanocurcumin significantly attenuated tin-induced neuroinflammation and neuronal damage. Treated rats showed downregulation of IL-6, MCP-1, and α-synuclein expression (<i>P</i> &lt; 0.05), increased SOD activity, and decreased MDA levels (<i>P</i> &lt; 0.05). Serum Ca2⁺ levels were elevated in the nanocurcumin group, potentially reflecting reduced accumulation in brain tissues. Nanocurcumin mitigates tin chloride-induced neurotoxicity via antioxidant and anti-inflammatory mechanisms, indicating its potential as a therapeutic candidate for Parkinson’s disease.</p>

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The neuroprotective effects of nanocurcumin on Parkinson’s disease markers in rats exposed to tin chloride

  • 期刊论文

  • 发表日期：

    2025年7月10日

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  • Saedolah Golmoradi,
  • Najmeh Ranji,
  • Mahdi Shahriarinour,
  • Eisa Vefghi

摘要

Tin chloride, a heavy metal compound, induces neurotoxicity and is associated with Parkinson’s disease (PD), a condition characterized by inflammation and oxidative stress. Curcumin, a polyphenolic compound, is widely recognized for its antioxidant and anti-inflammatory properties. This study examined the neuroprotective effects of nanocurcumin in a rat model of PD induced by tin (II) chloride. 20 Wistar rats were randomly assigned to four groups (n = 5/group): control, nanocurcumin (20 mg/kg), tin chloride, and tin chloride + nanocurcumin. After 4 weeks, brain tissues were analyzed histologically and for expression of inflammatory markers (IL-6, MCP-1, α-synuclein). Serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), calcium (Ca2⁺), and tin were also measured. Nanocurcumin significantly attenuated tin-induced neuroinflammation and neuronal damage. Treated rats showed downregulation of IL-6, MCP-1, and α-synuclein expression (P < 0.05), increased SOD activity, and decreased MDA levels (P < 0.05). Serum Ca2⁺ levels were elevated in the nanocurcumin group, potentially reflecting reduced accumulation in brain tissues. Nanocurcumin mitigates tin chloride-induced neurotoxicity via antioxidant and anti-inflammatory mechanisms, indicating its potential as a therapeutic candidate for Parkinson’s disease.