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<p>Plant-derived bioactive compounds have garnered significant interest due to their potent therapeutic benefits, including antimicrobial, anti-inflammatory, and anticancer activities. However, their clinical application is hampered by inherent drawbacks such as poor solubility, chemical instability, and lack of multifunctionality in conventional formulations. Addressing these limitations, we report the green synthesis of a multifunctional nanocomposite composed of curcumin (phytochemical), chitosan (biopolymer), aloe vera (natural stabilizer), and graphite nanosheets (nanocarbon reinforcement) aimed at combined infection control and liver cancer therapy. The nanocomposite exhibited hydrodynamic sizes in the range of approximately 700 to 850&#xa0;nm and demonstrated a positive surface charge (+ 51.1 mV), indicative of high colloidal stability. Fourier Transform Infrared (FTIR) Spectroscopy analysis confirmed successful integration of each component through characteristic functional groups. Biological evaluations revealed potent antimicrobial activity against clinically relevant pathogens such as <i>Staphylococcus aureus</i> and <i>Candida albicans</i>, alongside significant anti-inflammatory effects exemplified by membrane stabilization and hemolysis inhibition in erythrocyte assays. Crucially, the nanocomposite showed dose-dependent cytotoxicity toward HepG2 liver carcinoma cells (IC₅₀ ≈ 60&#xa0;µg/mL), with associated apoptotic morphological changes. The synergistic assembly of phytochemicals, biosafe polymers, and nanocarbons into a single eco-friendly platform offers a promising approach to effectively address oxidative stress, microbial infections, and tumor progression, positioning this nanocomposite as a sustainable candidate for future biomedical applications.</p>

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Graphite nanopowder-enhanced curcumin-chitosan-aloe vera nanocomposite as a green multifunctional platform for anti inflammatory and liver cancer therapy

  • 期刊论文

  • 发表日期：

    2025年12月24日

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  • Swetha Santhanam,
  • Tanima Bhattacharya,
  • Tanmoy Das

摘要

Plant-derived bioactive compounds have garnered significant interest due to their potent therapeutic benefits, including antimicrobial, anti-inflammatory, and anticancer activities. However, their clinical application is hampered by inherent drawbacks such as poor solubility, chemical instability, and lack of multifunctionality in conventional formulations. Addressing these limitations, we report the green synthesis of a multifunctional nanocomposite composed of curcumin (phytochemical), chitosan (biopolymer), aloe vera (natural stabilizer), and graphite nanosheets (nanocarbon reinforcement) aimed at combined infection control and liver cancer therapy. The nanocomposite exhibited hydrodynamic sizes in the range of approximately 700 to 850 nm and demonstrated a positive surface charge (+ 51.1 mV), indicative of high colloidal stability. Fourier Transform Infrared (FTIR) Spectroscopy analysis confirmed successful integration of each component through characteristic functional groups. Biological evaluations revealed potent antimicrobial activity against clinically relevant pathogens such as Staphylococcus aureus and Candida albicans, alongside significant anti-inflammatory effects exemplified by membrane stabilization and hemolysis inhibition in erythrocyte assays. Crucially, the nanocomposite showed dose-dependent cytotoxicity toward HepG2 liver carcinoma cells (IC₅₀ ≈ 60 µg/mL), with associated apoptotic morphological changes. The synergistic assembly of phytochemicals, biosafe polymers, and nanocarbons into a single eco-friendly platform offers a promising approach to effectively address oxidative stress, microbial infections, and tumor progression, positioning this nanocomposite as a sustainable candidate for future biomedical applications.