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<p>The increasing incidence of skin cancer, antimicrobial resistance, and oxidative stress-related conditions necessitates the development of multifunctional therapeutic agents. The main objectives of this investigation is synthesis, characterization, and biomedical assessment of silver nanoparticles (AgNPs) synthesized via a modified Turkevich method using trisodium citrate and SDS as reducing and capping agents. Characterization through ultraviolet–visible (UV–Vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, zeta potential analysis, and field-emission scanning electron microscopy (FE-SEM) confirmed the successful formation of stable, spherical AgNPs with sizes ranging from 21.99 to 41.35 nm and a moderately stable surface charge (− 27.24 mV). Biological evaluations demonstrated the dose-dependent cytotoxicity of AgNPs against A375 melanoma skin cancer cells, with significant reduction in cell viability at higher concentrations. Antibacterial assessment against <i>Staphylococcus aureus</i> (<i>S. aureus)</i> revealed strong, concentration-dependent inhibition zones, highlighting the AgNPs potential in combating resistant skin infections. Additionally, AgNPs exhibited noteworthy antioxidant activity in DPPH assays, although slightly lower than standard ascorbic acid. The results suggest that the synthesized AgNPs possess potent triple-functional activity, including anticancer, antibacterial, and antioxidant activity, supporting their applicability in integrated therapeutic strategies for skin-related conditions.</p>

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Silver nanoparticles as a triple-action agent: therapeutic potential in skin cancer, skin infections, and antioxidant activity

  • 期刊论文

  • 发表日期：

    2025年9月17日

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  • Karrar R. Mohammed,
  • Ridha A. Hussein,
  • Hussein Abbood Awad,
  • Mohammed S. Al-Hindawi

摘要

The increasing incidence of skin cancer, antimicrobial resistance, and oxidative stress-related conditions necessitates the development of multifunctional therapeutic agents. The main objectives of this investigation is synthesis, characterization, and biomedical assessment of silver nanoparticles (AgNPs) synthesized via a modified Turkevich method using trisodium citrate and SDS as reducing and capping agents. Characterization through ultraviolet–visible (UV–Vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, zeta potential analysis, and field-emission scanning electron microscopy (FE-SEM) confirmed the successful formation of stable, spherical AgNPs with sizes ranging from 21.99 to 41.35 nm and a moderately stable surface charge (− 27.24 mV). Biological evaluations demonstrated the dose-dependent cytotoxicity of AgNPs against A375 melanoma skin cancer cells, with significant reduction in cell viability at higher concentrations. Antibacterial assessment against Staphylococcus aureus (S. aureus) revealed strong, concentration-dependent inhibition zones, highlighting the AgNPs potential in combating resistant skin infections. Additionally, AgNPs exhibited noteworthy antioxidant activity in DPPH assays, although slightly lower than standard ascorbic acid. The results suggest that the synthesized AgNPs possess potent triple-functional activity, including anticancer, antibacterial, and antioxidant activity, supporting their applicability in integrated therapeutic strategies for skin-related conditions.