Scholarlink

<p>This study reports the development of zinc oxide nanoparticles (ZnO NPs) through an eco-friendly, microwave-assisted method using <i>Citrus</i> × <i>aurantiifolia</i> (Christm.) Swingle fruit peel extract as a sustainable resource. Analysis of the produced ZnO NPs verified their spherical shape and hexagonal wurtzite crystal structure. Tests for biocompatibility demonstrated low toxicity to cells from mammals, indicating their potential safe use in biomedical applications. Evaluation of antibacterial properties revealed substantial inhibition of bacterial growth in uropathogenic strains, with minimum inhibitory concentrations (MICs) determined as 7.5&#xa0;µg/mL for <i>Acinetobacter</i> sp., <i>Enterobacter</i> sp., and <i>Klebsiella pneumoniae</i>; 10&#xa0;µg/mL for <i>Proteus mirabilis</i>; and 12.5&#xa0;µg/mL for <i>Escherichia coli</i>. These results underscore the potential of ZnO NPs as effective antimicrobial agents, offering promising applications in combating urinary tract infections (UTIs) and addressing the critical issue of antimicrobial resistance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Antibacterial activity of biosynthesized nano-zinc oxide from Citrus × aurantiifolia (christm.) Swingle fruit peel against uropathogenic clinical isolates: an in vitro study

  • 期刊论文

  • 发表日期：

    2025年4月24日

查看全文
  • Sana S. Shaikh,
  • Supriya M. Kale,
  • Navjeet K. Lotey,
  • Manish S. Hate,
  • Ramesh S. Chaughule

摘要

This study reports the development of zinc oxide nanoparticles (ZnO NPs) through an eco-friendly, microwave-assisted method using Citrus × aurantiifolia (Christm.) Swingle fruit peel extract as a sustainable resource. Analysis of the produced ZnO NPs verified their spherical shape and hexagonal wurtzite crystal structure. Tests for biocompatibility demonstrated low toxicity to cells from mammals, indicating their potential safe use in biomedical applications. Evaluation of antibacterial properties revealed substantial inhibition of bacterial growth in uropathogenic strains, with minimum inhibitory concentrations (MICs) determined as 7.5 µg/mL for Acinetobacter sp., Enterobacter sp., and Klebsiella pneumoniae; 10 µg/mL for Proteus mirabilis; and 12.5 µg/mL for Escherichia coli. These results underscore the potential of ZnO NPs as effective antimicrobial agents, offering promising applications in combating urinary tract infections (UTIs) and addressing the critical issue of antimicrobial resistance.