<p>This study aims to optimize the preparation conditions of CeO₂-zeolite (CeO₂-Z) catalyst and its application in the CeO₂-Z/O₃ catalytic oxidation system for pretreatment of wastewater containing organic peroxides. Through the response surface experiment method, the single-factor influence degree and interactive influence degree of the concentration of Ce³⁺, exchange duration, and exchange number of the preparation catalyst CeO₂-Z, as well as the optimization of these preparation conditions, were analyzed. The experimental results indicate that the optimal preparation conditions for the CeO₂-Z catalyst are a Ce³⁺ concentration of 0.25&#xa0;mol/L, a water bath duration of 16&#xa0;h, and an impregnation number of 2. The catalyst prepared under these conditions exhibited excellent performance and had low economic cost. When the catalyst is applied to the pretreatment of ozone-catalyzed oxidation wastewater containing organic peroxide, the removal efficiencies of chemical oxygen demand (COD) and Ultraviolet absorbance at 254&#xa0;nm (UV₂₅₄) are 33.42% and 23.81%, which shows that the removal effect is good. The CeO₂-Z catalyst was characterized by X-ray diffraction (XRD) and energy-dispersive spectroscopy (EDS), and the results showed that CeO₂ was successfully attached to the zeolite. The five-day biological oxygen demand (BOD₅) and COD ratio (B/C) of the wastewater treated with CeO₂-Z/O₃ catalytic system pre-treatment increased from 0.093 to 0.105 to 0.154–0.158, indicating that the CeO₂-Z catalyst can significantly improve the biodegradability of the wastewater. In conclusion, the CeO₂-Z catalyst shows great promise for application in the ozone catalytic oxidation pretreatment of wastewater containing organic peroxides due to its straightforward preparation process and exceptional performance.</p>