<p>The electro-peroxone process, as an advanced oxidation technology, has gained increasing attention for its effectiveness in wastewater treatment and pollutant removal. This process combines electrochemical oxidation with the in situ generation of hydrogen peroxide through electrolysis, which significantly enhances the degradation of contaminants. The objective of this study is to conduct a systematic review of research related to the electro-peroxone process during the period from 2014 to 2024. To this end, a comprehensive search was performed in reputable databases including Scopus, PubMed, ScienceDirect, and Web of Science. Key parameters examined include the type of pollutant, optimal pH, initial pollutant concentration, optimal reaction time, type of cathode and anode, flow rate, and current density, all analyzed in detail. Out of 279 screened articles, 72 met the inclusion criteria. In these studies, the removal efficiency of pollutants through the electro-peroxone process was reported to exceed 50%, with some cases achieving up to 100% removal. These results underscore the high efficacy of this process in eliminating pollutants and highlight its potential to enhance existing wastewater treatment methods. This article serves as a valuable resource for researchers and engineers working in water and wastewater treatment, paving the way for future research avenues.</p> Graphical abstract <p></p>