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<p><i>Morchella esculenta</i> is highly valued for its culinary and medicinal properties, which has been traditionally used for therapeutic purposes, including immune modulation and treating metabolic disorders. This study aimed to investigate the phytochemical composition of <i>Morchella esculenta</i> extracts using GC–MS and explore their antidiabetic activity through in vitro assays and molecular docking. The phytoconstituents like n-Hexadecanoic acid, 9,12-Octadecadienoic acid, Oleic acid, and Ergosterol were identified in both chloroform and ethanolic extracts. The ethanolic extract contained additional phytoconstituents, including Squalene and Linoleic acid ethyl ester. The ethanolic and chloroform extracts exhibited significant inhibition against the alpha-amylase and alpha-glucosidase, showing inhibition levels comparable to acarbose as a standard drug. The IC<sub>50</sub> of ethanolic and chloroform extracts were observed significantly against alpha-amylase (92.77 and 137.50&#xa0;µg/ml) and alpha-glucosidase (86.22 and 122.95&#xa0;µg/ml). Further, a molecular docking study at five target enzymes of Diabetes mellitus revealed that Stigmasta-5,24(28)-dien-3-ol (3β) and Ergosterol act as antidiabetic agents. The findings suggest that <i>Morchella esculenta</i> extracts, particularly the ethanol extract, exhibit promising in vitro antidiabetic potential, which may be attributed to the presence of bioactive phytoconstituents. However, further studies involving compound isolation, cellular investigations, and in vivo validation are required to confirm their therapeutic potential.</p>

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Exploring the role of Morchella esculenta phytoconstituents in diabetes management: GC–MS, enzyme inhibition and molecular docking

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Akrit Verma,
  • Sanjeev Kumar Sahu

摘要

Morchella esculenta is highly valued for its culinary and medicinal properties, which has been traditionally used for therapeutic purposes, including immune modulation and treating metabolic disorders. This study aimed to investigate the phytochemical composition of Morchella esculenta extracts using GC–MS and explore their antidiabetic activity through in vitro assays and molecular docking. The phytoconstituents like n-Hexadecanoic acid, 9,12-Octadecadienoic acid, Oleic acid, and Ergosterol were identified in both chloroform and ethanolic extracts. The ethanolic extract contained additional phytoconstituents, including Squalene and Linoleic acid ethyl ester. The ethanolic and chloroform extracts exhibited significant inhibition against the alpha-amylase and alpha-glucosidase, showing inhibition levels comparable to acarbose as a standard drug. The IC50 of ethanolic and chloroform extracts were observed significantly against alpha-amylase (92.77 and 137.50 µg/ml) and alpha-glucosidase (86.22 and 122.95 µg/ml). Further, a molecular docking study at five target enzymes of Diabetes mellitus revealed that Stigmasta-5,24(28)-dien-3-ol (3β) and Ergosterol act as antidiabetic agents. The findings suggest that Morchella esculenta extracts, particularly the ethanol extract, exhibit promising in vitro antidiabetic potential, which may be attributed to the presence of bioactive phytoconstituents. However, further studies involving compound isolation, cellular investigations, and in vivo validation are required to confirm their therapeutic potential.