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<p>Chemotherapeutic agents used to treat colorectal cancer have many adverse side effects. As a result, researchers are investigating natural compounds to treat colorectal cancer. Curcumin is a natural polyphenol found in turmeric (<i>Curcuma longa)</i> with proven activity against colorectal cancer. It is a bioactive polyphenol that has drawn attention for its antioxidant, anti-inflammatory, antimicrobial, and most importantly,&#xa0;anticancer properties. However, curcumin’s lipophilic nature, poor bioavailability, rapid metabolism in the body, and unstable chemical nature represent major drawbacks to its successful therapeutic applications. Efficient nanoencapsulation methods of curcumin can enhance its physical, chemical, and pharmacological properties. Several nanoparticle-based curcumin formulations exist, such as liposomes, micelles, polymeric nanoparticles, cyclodextrin, nano gels, gold nanoparticles, etc., which improve free curcumin’s anticarcinogenic efficacy against colon cancer. We have conducted a comparative analysis of the properties of a few existing curcumin nanoparticles based on their various physicochemical, in vitro, and in vivo properties. Although these few nanoparticles do not represent all the nanoparticles developed to date, we believe this analysis will help in the development of novel and more effective curcumin nanoparticles for colorectal cancer (CRC) treatment, as we highlight existing research gaps in the development of nanoencapsulated curcumin.</p>

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Comparative analysis of curcumin nanoparticles for colon cancer treatment

  • 期刊论文

  • 发表日期：

    2026年3月31日

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  • Arunava Poddar,
  • Shubhojit Roy,
  • N. Vaishnavee Sudhakar,
  • Amrita Chatterjee,
  • Nageswaran Sivalingam

摘要

Chemotherapeutic agents used to treat colorectal cancer have many adverse side effects. As a result, researchers are investigating natural compounds to treat colorectal cancer. Curcumin is a natural polyphenol found in turmeric (Curcuma longa) with proven activity against colorectal cancer. It is a bioactive polyphenol that has drawn attention for its antioxidant, anti-inflammatory, antimicrobial, and most importantly, anticancer properties. However, curcumin’s lipophilic nature, poor bioavailability, rapid metabolism in the body, and unstable chemical nature represent major drawbacks to its successful therapeutic applications. Efficient nanoencapsulation methods of curcumin can enhance its physical, chemical, and pharmacological properties. Several nanoparticle-based curcumin formulations exist, such as liposomes, micelles, polymeric nanoparticles, cyclodextrin, nano gels, gold nanoparticles, etc., which improve free curcumin’s anticarcinogenic efficacy against colon cancer. We have conducted a comparative analysis of the properties of a few existing curcumin nanoparticles based on their various physicochemical, in vitro, and in vivo properties. Although these few nanoparticles do not represent all the nanoparticles developed to date, we believe this analysis will help in the development of novel and more effective curcumin nanoparticles for colorectal cancer (CRC) treatment, as we highlight existing research gaps in the development of nanoencapsulated curcumin.