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<p>Cocoa butter (CB) melts at close to human body temperature and could be used to encapsulate substances and improve their oral bioavailability. In this study, a solid dispersion of the poorly water-soluble polyphenol curcumin (Cur) in CB (Cur@CB) was prepared using oil-in-water emulsification. Cur in CB was mixed with an aqueous solution containing the dispersants sodium caseinate (CasNa) and sucrose fatty acid ester (L-1695), and then lyophilized. The apparent solubility of Cur in Cur@CB increased with increases in the masses of CasNa and L-1695. The surface charge of Cur@CB was dominated by the ampholyte CasNa and the apparent solubility was lowest near the isoelectric point of CasNa (approximately 4.5) and increased under neutral and acidic conditions. The particle size of Cur@CB fractionated by centrifugation and microfiltration was approximately 160&#xa0;nm, which suggested that Cur@CB was present as a hydrocolloid. The apparent solubility of Cur from Cur@CB after simulated in vitro digestion with protease and lipase was much greater than for a blank sample, which was not complexed with CasNa. The amount of Cur accumulated in a monolayer of Caco-2 cells (small intestine model) after Cur@CB simulated in vitro digestion was 10.6 times that of the blank. This solid dispersion greatly enhances the oral bioavailability of poorly water-soluble curcumin.</p>

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Enhanced bioaccessibility of curcumin incorporated in microparticles prepared using cocoa butter which has a moderate melting point

  • 期刊论文

  • 发表日期：

    2026年3月11日

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  • Arisa Taniguchi,
  • Tatsuya Oshima,
  • Asuka Inada

摘要

Cocoa butter (CB) melts at close to human body temperature and could be used to encapsulate substances and improve their oral bioavailability. In this study, a solid dispersion of the poorly water-soluble polyphenol curcumin (Cur) in CB (Cur@CB) was prepared using oil-in-water emulsification. Cur in CB was mixed with an aqueous solution containing the dispersants sodium caseinate (CasNa) and sucrose fatty acid ester (L-1695), and then lyophilized. The apparent solubility of Cur in Cur@CB increased with increases in the masses of CasNa and L-1695. The surface charge of Cur@CB was dominated by the ampholyte CasNa and the apparent solubility was lowest near the isoelectric point of CasNa (approximately 4.5) and increased under neutral and acidic conditions. The particle size of Cur@CB fractionated by centrifugation and microfiltration was approximately 160 nm, which suggested that Cur@CB was present as a hydrocolloid. The apparent solubility of Cur from Cur@CB after simulated in vitro digestion with protease and lipase was much greater than for a blank sample, which was not complexed with CasNa. The amount of Cur accumulated in a monolayer of Caco-2 cells (small intestine model) after Cur@CB simulated in vitro digestion was 10.6 times that of the blank. This solid dispersion greatly enhances the oral bioavailability of poorly water-soluble curcumin.