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<p>Fucoidan, a bioactive polysaccharide found in brown seaweed, is widely studied for its diverse health-promoting properties, offering promising potential for managing metabolic disorders, including oxidative stress and diabetes. This study investigates the physicochemical characteristics, antioxidant, and anti-diabetic properties of fucoidan extracted from <i>Sargassum binderi</i> (F<sub>sar</sub>). Fourier transform infrared spectroscopy (FTIR) spectrum confirmed the presence of key functional groups, with F<sub>sar</sub> containing fucose and sulfate at 30.53% and 22.12%, respectively. In comparison, the commercial fucoidan (F<sub>ysk</sub>) exhibited significantly lower fucose (27.94%) but higher sulfate (26.28%) content. F<sub>sar</sub> exhibited an equivalent total phenolic content (TPC; 34.32&#xa0;mg GAE/g) and demonstrated comparable antioxidant activities, including 1,1-diphenyl-2-picrylhydrazyl (DPPH; IC<sub>50</sub> 1.91&#xa0;mg/mL), superoxide anion (SOA; 14.96%), and hydroxyl radical (•OH; 54.89%) scavenging activities, relative to F<sub>ysk</sub>. In anti-diabetic studies using 3T3-L1 adipocytes, F<sub>sar</sub> showed a dose-dependent increase in glucose uptake, with a 65% enhancement observed at 0.5&#xa0;mg/mL, surpassing the effect of standard insulin. Additionally, F<sub>sar</sub> significantly inhibited lipid accumulation in adipocytes, with an approximate 66% reduction at the same concentration. These findings suggest that fucoidan from the underutilized Malaysian brown seaweed not only possesses strong antioxidant properties but also holds potential as a natural therapeutic agent for managing related metabolic disorders particularly, as an anti-diabetic.</p>

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Bioactive properties of fucoidan from Malaysian brown seaweed (Sargassum binderi) with an assessment of its anti-diabetic potential in 3T3-L1 adipocytes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月19日

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  • Nur Akmal Solehah Din,
  • Piyapat Aiemcharoen,
  • Decha Sermwittayawong,
  • Seng Joe Lim,
  • Ainaatul Asmaa’ Ishak,
  • Noor-Soffalina Sofian-Seng,
  • Noorul Syuhada Mohd Razali,
  • Hafeedza Abdul Rahman,
  • Wan Aida Wan Mustapha

摘要

Fucoidan, a bioactive polysaccharide found in brown seaweed, is widely studied for its diverse health-promoting properties, offering promising potential for managing metabolic disorders, including oxidative stress and diabetes. This study investigates the physicochemical characteristics, antioxidant, and anti-diabetic properties of fucoidan extracted from Sargassum binderi (Fsar). Fourier transform infrared spectroscopy (FTIR) spectrum confirmed the presence of key functional groups, with Fsar containing fucose and sulfate at 30.53% and 22.12%, respectively. In comparison, the commercial fucoidan (Fysk) exhibited significantly lower fucose (27.94%) but higher sulfate (26.28%) content. Fsar exhibited an equivalent total phenolic content (TPC; 34.32 mg GAE/g) and demonstrated comparable antioxidant activities, including 1,1-diphenyl-2-picrylhydrazyl (DPPH; IC50 1.91 mg/mL), superoxide anion (SOA; 14.96%), and hydroxyl radical (•OH; 54.89%) scavenging activities, relative to Fysk. In anti-diabetic studies using 3T3-L1 adipocytes, Fsar showed a dose-dependent increase in glucose uptake, with a 65% enhancement observed at 0.5 mg/mL, surpassing the effect of standard insulin. Additionally, Fsar significantly inhibited lipid accumulation in adipocytes, with an approximate 66% reduction at the same concentration. These findings suggest that fucoidan from the underutilized Malaysian brown seaweed not only possesses strong antioxidant properties but also holds potential as a natural therapeutic agent for managing related metabolic disorders particularly, as an anti-diabetic.