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Background <p>Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm most commonly arising from the pleura, with abdominopelvic occurrence being uncommon and diagnostically challenging. This study evaluates the clinicopathological features, management, and risk stratification of abdominopelvic SFTs at a tertiary cancer center.</p> Methods <p>A retrospective review was performed of all histologically confirmed abdominopelvic SFTs diagnosed between January and December 2021. Inclusion criteria comprised primary abdominopelvic SFTs with complete histopathological and immunohistochemical evaluation; cases with incomplete data were excluded. Clinical, radiological, histopathological, immunohistochemical, molecular, treatment, and follow-up details were analyzed. Metastatic risk was assessed using the modified four-variable model.</p> Results <p>Four cases were identified (median age 54 years; range 45–60; female-to-male ratio 3:1). Tumor sites included omentum, retroperitoneum, parametrium, and periprostatic region. Tumor size ranged from 6 to 23&#xa0;cm (median 14.5&#xa0;cm). All patients underwent complete surgical excision. Histologically, three tumors showed classic patternless architecture with diffuse CD34 and STAT6 positivity. One omental tumor demonstrated dedifferentiated morphology with necrosis and high mitotic activity, with strong CD34 and patchy STAT6 expression; NAB2–STAT6 fusion was confirmed. Risk stratification categorized three tumors as low to intermediate risk and one as high risk. At 48 months follow-up, the high-risk patient developed progressive disease at 18 months and died at 20 months despite adjuvant radiotherapy, while the remaining patients remain disease-free.</p> Conclusion <p>Abdominopelvic SFTs require multimodal diagnosis integrating morphology, immunohistochemistry, and molecular analysis. Complete surgical excision remains the mainstay of management, and risk stratification is essential for prognostication and guiding adjuvant therapy.</p> Graphical Abstract <p></p>

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Abdominopelvic Solitary Fibrous Tumors: Clinicopathological Features, Clinical Management, and Risk Stratification – A One-Year Case Series from a Tertiary Care Cancer Center

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Lakshmy S. Kumar,
  • Sindhu Nair P,
  • Deepthi B,
  • Thara Somanathan,
  • Siva Ranjith J

摘要

Background

Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm most commonly arising from the pleura, with abdominopelvic occurrence being uncommon and diagnostically challenging. This study evaluates the clinicopathological features, management, and risk stratification of abdominopelvic SFTs at a tertiary cancer center.

Methods

A retrospective review was performed of all histologically confirmed abdominopelvic SFTs diagnosed between January and December 2021. Inclusion criteria comprised primary abdominopelvic SFTs with complete histopathological and immunohistochemical evaluation; cases with incomplete data were excluded. Clinical, radiological, histopathological, immunohistochemical, molecular, treatment, and follow-up details were analyzed. Metastatic risk was assessed using the modified four-variable model.

Results

Four cases were identified (median age 54 years; range 45–60; female-to-male ratio 3:1). Tumor sites included omentum, retroperitoneum, parametrium, and periprostatic region. Tumor size ranged from 6 to 23 cm (median 14.5 cm). All patients underwent complete surgical excision. Histologically, three tumors showed classic patternless architecture with diffuse CD34 and STAT6 positivity. One omental tumor demonstrated dedifferentiated morphology with necrosis and high mitotic activity, with strong CD34 and patchy STAT6 expression; NAB2–STAT6 fusion was confirmed. Risk stratification categorized three tumors as low to intermediate risk and one as high risk. At 48 months follow-up, the high-risk patient developed progressive disease at 18 months and died at 20 months despite adjuvant radiotherapy, while the remaining patients remain disease-free.

Conclusion

Abdominopelvic SFTs require multimodal diagnosis integrating morphology, immunohistochemistry, and molecular analysis. Complete surgical excision remains the mainstay of management, and risk stratification is essential for prognostication and guiding adjuvant therapy.

Graphical Abstract