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<p>Increased microvessel density (MVD) can be associated with tumor progression and poor prognosis in epithelial ovarian tumors. This study investigated the association of MVD with subtypes and staging of epithelial ovarian tumors. This cohort study reviewed the medical profiles of 121 patients with epithelial ovarian tumors (98 malignant and 23 borderline) referred to Imam Hossein Hospital, affiliated with Shahid Beheshti University of Medical Sciences, between 2019 and 2024. The World Health Organization (WHO 2020) classification of tumors was used to assess histological subtypes. Immunohistochemically staining was performed with anti-cluster of differentiation (CD31) antibody. The analySIS program was used to examine the images to assess MVD (vessels/mm<sup>2</sup>). Multivariate analysis was used to assess the association of MVD with tumor type, subtypes, and tumor stage. Based on histological findings, 75 (62%) were serous type, 17 (14%) endometrioid, 27 (22.3%) mucinous type, and 2 (1.7%) clear cell. In terms of histological grade, 53 (54.1) were high grade, and 45 (45.9%) were low grade. Multivariate analysis showed that MVD was significantly associated with malignant tumor type (OR<sub>adjusted</sub> 1.61; 95% CI 1.11, 2.12; <i>P</i> 0.001), endometrioid tumor subtype versus serous and mucinous subtype (OR<sub>adjusted</sub> 1.46; 95% CI 1.05, 1.87; <i>P</i> 0.009), and tumor stage &gt; II (OR<sub>adjusted</sub> 2.01; 95% CI 1.09, 2.93; <i>P</i> 0.004). Our study showed that higher MVD was associated with the malignant type of tumor. The median MVD was higher in the endometrioid subtype than in the serous subtype.</p>

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Association of Microvessel Density with Subtypes and Staging of Ovarian Epithelial Tumors: A Retrospective Cohort Study

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Maryam Sadat Hosseini,
  • Marzieh Mohammadi,
  • Ali Rahbari,
  • Mahshid Vasef,
  • Maliheh Arab,
  • Farah Farzaneh,
  • Maryam Talayeh,
  • Nooshin Afshar Moghaddam,
  • Fatemeh Dastyar

摘要

Increased microvessel density (MVD) can be associated with tumor progression and poor prognosis in epithelial ovarian tumors. This study investigated the association of MVD with subtypes and staging of epithelial ovarian tumors. This cohort study reviewed the medical profiles of 121 patients with epithelial ovarian tumors (98 malignant and 23 borderline) referred to Imam Hossein Hospital, affiliated with Shahid Beheshti University of Medical Sciences, between 2019 and 2024. The World Health Organization (WHO 2020) classification of tumors was used to assess histological subtypes. Immunohistochemically staining was performed with anti-cluster of differentiation (CD31) antibody. The analySIS program was used to examine the images to assess MVD (vessels/mm2). Multivariate analysis was used to assess the association of MVD with tumor type, subtypes, and tumor stage. Based on histological findings, 75 (62%) were serous type, 17 (14%) endometrioid, 27 (22.3%) mucinous type, and 2 (1.7%) clear cell. In terms of histological grade, 53 (54.1) were high grade, and 45 (45.9%) were low grade. Multivariate analysis showed that MVD was significantly associated with malignant tumor type (ORadjusted 1.61; 95% CI 1.11, 2.12; P 0.001), endometrioid tumor subtype versus serous and mucinous subtype (ORadjusted 1.46; 95% CI 1.05, 1.87; P 0.009), and tumor stage > II (ORadjusted 2.01; 95% CI 1.09, 2.93; P 0.004). Our study showed that higher MVD was associated with the malignant type of tumor. The median MVD was higher in the endometrioid subtype than in the serous subtype.