<p>People with physical and/or sensory disability have lower uptake of breast, cervical, and colorectal cancer screening than those without disability. This systematic review aims to identify evidence-based interventions designed to positively influence cancer screening participation for people with physical and/or sensory disability. Databases were searched for peer-reviewed studies reporting interventions targeting breast, cervical, and/or colorectal cancer screening for people with physical and/or sensory disability. A qualitative review of the results formed a narrative synthesis. Fifteen studies published between 1995–2022 from the USA, Turkey and Saudi Arabia were included in the review, involving people who were d/Deaf (<i>n</i> = 10), people with physical disability (<i>n</i> = 4), and people with cognitive, hearing, vision or physical disability (<i>n</i> = 1). The interventions included cancer and cancer screening education (<i>n</i> = 13) and environmental interventions that modified healthcare facilities (<i>n</i> = 2). Most educational interventions increased cancer screening knowledge but only some increased screening participation. The environmental interventions showed promising but non-significant effects on screening participation. Despite critical gaps in the literature, this review provides a foundation to develop interventions needed to improve cancer screening participation among people with physical and/or sensory disability.</p>