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Introduction <p>2,4-dinitrophenol (DNP) is an uncoupler of oxidative phosphorylation and is highly toxic in overdose.</p> Case Report <p>We present a case of an 18-year-old female who survived an acute-on-chronic DNP overdose resulting in hypermetabolic state and widespread ST depression with associated troponin I elevation. Serial DNP levels are plotted for this patient, demonstrating first order kinetics with a half-life of 18&#xa0;h.</p> Discussion <p>Survival in this case may be attributed to early management of hyperthermia and hypermetabolic state, as well as the acute-on-chronic nature of the overdose. Human pharmacokinetic data for DNP in overdose are rare, as are cases with ST-segment changes.</p>

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Survival of Acute-on-Chronic 2,4-Dinitrophenol Overdose with Associated Pharmacokinetics

  • 期刊论文

  • 发表日期：

    2025年11月17日

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  • Annie Silvester,
  • Zeff Koutsogiannis,
  • Stacey Richards,
  • David Thomson,
  • Anselm Wong

摘要

Introduction

2,4-dinitrophenol (DNP) is an uncoupler of oxidative phosphorylation and is highly toxic in overdose.

Case Report

We present a case of an 18-year-old female who survived an acute-on-chronic DNP overdose resulting in hypermetabolic state and widespread ST depression with associated troponin I elevation. Serial DNP levels are plotted for this patient, demonstrating first order kinetics with a half-life of 18 h.

Discussion

Survival in this case may be attributed to early management of hyperthermia and hypermetabolic state, as well as the acute-on-chronic nature of the overdose. Human pharmacokinetic data for DNP in overdose are rare, as are cases with ST-segment changes.