Introduction <p>This descriptive study examines the relationships between gender and sexual diversity, age, basic needs, victimization/discrimination, depressive symptomology, general health, and quality of life among the Global Pride participants in India. We situate our analysis within India’s unique socio-cultural and legal landscape, which shapes these experiences.</p> Methods <p>Data were collected in 2022 from 55 gender and sexually diverse individuals through an online survey. Descriptive statistics were conducted, and regression analyses were used to explore the associations and key predictors of the outcomes.</p> Results <p>The participants reported high rates of victimization (e.g., 67.3% verbally insulted; 25.5% threatened with physical violence; 18.2% sexually attacked) and discrimination (e.g., 25% experienced discrimination in the workplace; 47.3% lost a friend). Regression analyses revealed that victimization/discrimination had a negative impact on general health (<i>b</i> = -0.09, <i>p</i> = .005) and a positive association with depressive symptoms (<i>b</i> = 0.25, <i>p</i> = .038), while age was negatively associated with depressive symptoms (<i>b</i> = − 0.20, <i>p</i> = .001). Additionally, the ability to meet basic needs had a positive impact on quality of life (<i>b</i> = 0.76, <i>p</i> = .021).</p> Conclusions <p>The findings highlight significant challenges faced by gender and sexually diverse individuals, particularly due to victimization and discrimination, despite meeting basic needs.</p> Implications <p>Inclusive health policies, anti-victimization and discrimination laws, and culturally sensitive support systems are essential to improving the health and quality of life of gender and sexually diverse individuals in India. Addressing structural inequities are also needed to support the dignity and equity of these marginalized populations.</p>