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<p>Contemporary global migration, driven by socioeconomic instability, armed conflict, climate change, and political factors, has emerged as a major determinant of exposome reconfiguration and cardiometabolic vulnerability. Migrant populations are disproportionately exposed to cumulative environmental, psychosocial, behavioral, and cultural stressors that may contribute to chronic low-grade inflammation, neuroendocrine dysregulation, metabolic dysfunction, and increased cardiovascular disease (CVD) risk across the life course. Within the framework of predictive, preventive, and personalized medicine (PPPM/3 PM), migration should not be viewed solely as a demographic phenomenon, but rather as a dynamic process capable of reshaping individual exposure profiles and biological responses. Environmental pollution, dietary acculturation, psychosocial stress, sleep disruption, climate-related exposures, social vulnerability, and barriers to healthcare interact to modulate the gut–brain axis, microbiota composition, inflammatory pathways, and cardiometabolic outcomes. This narrative review discusses migration as a driver of exposome-mediated cardiovascular risk and explores how exposome science may support risk stratification, early identification of vulnerable populations, and targeted preventive strategies in migrant individuals. Furthermore, we discuss the potential role of biomarkers, digital health technologies, and multi-omics approaches in enabling more personalized and culturally sensitive interventions. By integrating migration, exposome science, and PPPM principles, this review proposes a shift from generalized, reactive healthcare models toward more proactive, mechanism-based, and precision-oriented approaches to cardiometabolic prevention in migrant populations.</p>

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Migration-driven exposome reconfiguration: a predictive, preventive and personalized medicine perspective on cardiometabolic risk

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月8日

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  • Livia Alvarenga,
  • Ribanna Aparecida Marques Braga,
  • Júlia Galbiati de Souza,
  • Carla Soraya Costa Maia,
  • Denise Mafra,
  • Elizabeth Aparecida Ferraz da Silva Torres,
  • Nágila Raquel Teixeira Damasceno

摘要

Contemporary global migration, driven by socioeconomic instability, armed conflict, climate change, and political factors, has emerged as a major determinant of exposome reconfiguration and cardiometabolic vulnerability. Migrant populations are disproportionately exposed to cumulative environmental, psychosocial, behavioral, and cultural stressors that may contribute to chronic low-grade inflammation, neuroendocrine dysregulation, metabolic dysfunction, and increased cardiovascular disease (CVD) risk across the life course. Within the framework of predictive, preventive, and personalized medicine (PPPM/3 PM), migration should not be viewed solely as a demographic phenomenon, but rather as a dynamic process capable of reshaping individual exposure profiles and biological responses. Environmental pollution, dietary acculturation, psychosocial stress, sleep disruption, climate-related exposures, social vulnerability, and barriers to healthcare interact to modulate the gut–brain axis, microbiota composition, inflammatory pathways, and cardiometabolic outcomes. This narrative review discusses migration as a driver of exposome-mediated cardiovascular risk and explores how exposome science may support risk stratification, early identification of vulnerable populations, and targeted preventive strategies in migrant individuals. Furthermore, we discuss the potential role of biomarkers, digital health technologies, and multi-omics approaches in enabling more personalized and culturally sensitive interventions. By integrating migration, exposome science, and PPPM principles, this review proposes a shift from generalized, reactive healthcare models toward more proactive, mechanism-based, and precision-oriented approaches to cardiometabolic prevention in migrant populations.