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<p>Telemedicine, a patient-centric innovative healthcare delivery model, leverages advanced telecommunication technologies to transmit medical data and services, seamlessly integrating the roles of physicians, patients, and facilitators. By optimizing doctor-patient interaction pathways, it not only eliminates geographical barriers and enhances access to healthcare but also empowers the practical implementation of Predictive, Preventive, and Personalized Medicine (PPPM). An open, distributed telemedicine system comprises remote diagnosis, expert consultation, information services, online examination, and distance learning—serves as a cornerstone for shifting the medical model from reactive treatment to proactive health management. This article reviews the current status and future directions of telemedicine within the PPPM framework, elaborating on the latest advances in predictive diagnostics, preventive strategies, and personalized treatment approaches. Specifically, it highlights telemedicine’s significance in optimizing healthcare resource allocation and improving service quality and efficiency—particularly noting that healthcare practitioners can conduct timely condition evaluations using dynamically collected remote data, reducing follow-up delays and enabling earlier diagnosis than traditional methods. Additionally, the article analyses key challenges confronting telemedicine, such as technological constraints, medical professionalism requirements, user acceptability, legal and regulatory gaps, policy limitations, operational management hurdles, and reimbursement issues, and proposes targeted strategies for broader implementation. Looking ahead, telemedicine will become better integrated with the traditional healthcare system under the aegis of the PPPM paradigm with the help of emerging technologies like robotics, 5G, the Internet of Things (IoT), and AI, paving the way for development of smart, predictive and personalized healthcare service models. With these technologies, the theoretical development and clinical application of PPPM will accelerate, thus boosting the high-quality development of global health systems.</p> Graphical abstract <p></p>

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Transforming telemedicine through predictive, preventive, and personalized medicine (PPPM): innovations, challenges, and future directions

  • 期刊论文

  • 发表日期：

    2026年2月14日

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  • Yufan Yang,
  • Wangzheqi Zhang,
  • Chang Liu,
  • Haoling Zhang,
  • Xinyu Shen,
  • Yan Liao,
  • Wenwen Shi,
  • Li Gui

摘要

Telemedicine, a patient-centric innovative healthcare delivery model, leverages advanced telecommunication technologies to transmit medical data and services, seamlessly integrating the roles of physicians, patients, and facilitators. By optimizing doctor-patient interaction pathways, it not only eliminates geographical barriers and enhances access to healthcare but also empowers the practical implementation of Predictive, Preventive, and Personalized Medicine (PPPM). An open, distributed telemedicine system comprises remote diagnosis, expert consultation, information services, online examination, and distance learning—serves as a cornerstone for shifting the medical model from reactive treatment to proactive health management. This article reviews the current status and future directions of telemedicine within the PPPM framework, elaborating on the latest advances in predictive diagnostics, preventive strategies, and personalized treatment approaches. Specifically, it highlights telemedicine’s significance in optimizing healthcare resource allocation and improving service quality and efficiency—particularly noting that healthcare practitioners can conduct timely condition evaluations using dynamically collected remote data, reducing follow-up delays and enabling earlier diagnosis than traditional methods. Additionally, the article analyses key challenges confronting telemedicine, such as technological constraints, medical professionalism requirements, user acceptability, legal and regulatory gaps, policy limitations, operational management hurdles, and reimbursement issues, and proposes targeted strategies for broader implementation. Looking ahead, telemedicine will become better integrated with the traditional healthcare system under the aegis of the PPPM paradigm with the help of emerging technologies like robotics, 5G, the Internet of Things (IoT), and AI, paving the way for development of smart, predictive and personalized healthcare service models. With these technologies, the theoretical development and clinical application of PPPM will accelerate, thus boosting the high-quality development of global health systems.

Graphical abstract