Scholarlink

<p>Depression is a prevalent mental health disorder with significant global impact, often accompanied by alterations in brain activity and neurotransmitter systems. Nuclear medicine, especially Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT), offers valuable insights into the neurobiological mechanisms underlying depression. These imaging modalities enable non-invasive assessment of cerebral glucose metabolism, neurotransmitter activity, and cerebral blood flow, which are often disrupted in individuals with depression. Advanced radiopharmaceuticals, including <sup>18</sup>F-FDG PET, <sup>123</sup>I-ADAM SPECT, and <sup>11</sup>C-raclopride PET, have been utilized to explore the pathophysiology of depression and monitor responses to various treatment strategies. This review discusses how nuclear medicine enhances the diagnosis, understanding, and personalized management of depression, with potential for guiding therapeutic interventions based on brain activity patterns and treatment responses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Nuclear Medicine in Depression: Insights into Brain Metabolism and Treatment Responses: a Literature Review

  • 期刊论文

  • 发表日期：

    2025年11月14日

查看全文
  • Raydel BrianKwee Amalo,
  • Hendra Budiawan,
  • Achmad Hussein Sundawa Kartamihardja

摘要

Depression is a prevalent mental health disorder with significant global impact, often accompanied by alterations in brain activity and neurotransmitter systems. Nuclear medicine, especially Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT), offers valuable insights into the neurobiological mechanisms underlying depression. These imaging modalities enable non-invasive assessment of cerebral glucose metabolism, neurotransmitter activity, and cerebral blood flow, which are often disrupted in individuals with depression. Advanced radiopharmaceuticals, including 18F-FDG PET, 123I-ADAM SPECT, and 11C-raclopride PET, have been utilized to explore the pathophysiology of depression and monitor responses to various treatment strategies. This review discusses how nuclear medicine enhances the diagnosis, understanding, and personalized management of depression, with potential for guiding therapeutic interventions based on brain activity patterns and treatment responses.