<p>Changing and diversifying a country’s export structure through the application of knowledge and a strategic focus on innovation plays a pivotal role in fostering sustainable economic growth. Production of high-technology products constitutes a fundamental source of competitive advantage that drives economic prosperity and enhances export performance. Globalization acts as a facilitator in this process, accelerating the diffusion of innovation and market expansion. This study conducts an investigation the interactive effect of innovation, both inputs and outputs of innovation, and globalization on high-technology export among leading science-producing countries from 2011 to 2021. By employing panel data analysis and the Generalized Method of Moments (GMM), the empirical findings validate the positive and significant effect of innovation integration on high-technology export performance. Specifically, the results demonstrate that, under conditions of heightened globalization, enhancements in any component of the innovation system contribute substantially to the growth of high-technology export.</p>