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<p>Medicinal plants play a crucial role in providing essential nutrients and active pharmaceutical compounds with anticancer, antibiotic or antimicrobial properties. Improvement of specialized metabolites biosynthesis or decreasing the production cost accompanied with identification and characterization of new genes, yield improvement or biotic/abiotic stress resistance are the preliminary criteria of medicinal plant improvement. Advanced genetic engineering techniques, including transformation and genome editing tools like CRISPR/Cas9 enable molecular scientists to manipulate genes with remarkable precision and efficiency. CRISPR enables the simultaneous targeted editing of multiple genes that control key traits in medicinal plants, allowing for the efficient and accurate development of ideal plant varieties. Researchers can employ appropriate research methodologies to design CRISPR/Cas9 systems for the targeted deletion of harmful genetic elements or the introduction of gain-of-function mutations, enabling precise genome editing in medicinal plants. This technology significantly accelerates the genetic improvement and germplasm innovation. This review explores global trends in this research by conducting a bibliometric analysis of Scopus data (2013–2025), focusing on publication output, average annual citations, international collaborations, keyword usage (via word clouds, co-occurrence networks, and overlay visualizations), and thematic evaluations. The analysis revealed a significant rise in directed mutagenesis vis-à-vis Crispr/Cas9 related studies in medicinal plants across countries, especially in China, USA and India. This review also explores the use of various gene editing approaches especially CRISPR/Cas9 technology and its future prospects to enhance the nutritive values and other characters of medicinal crops.</p>

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Directed mutagenesis vis-à-vis crispr/cas in improving medicinal plants: a review and bibliometric analysis

  • 期刊论文

  • 发表日期：

    2025年8月25日

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  • Poulomi Sen,
  • Rounaq Ansari,
  • Avishek Chatterjee,
  • Bipradeep Mondal,
  • Sudip Sengupta,
  • Subhadwip Ghorai,
  • Suvojit Bose,
  • Soham Hazra

摘要

Medicinal plants play a crucial role in providing essential nutrients and active pharmaceutical compounds with anticancer, antibiotic or antimicrobial properties. Improvement of specialized metabolites biosynthesis or decreasing the production cost accompanied with identification and characterization of new genes, yield improvement or biotic/abiotic stress resistance are the preliminary criteria of medicinal plant improvement. Advanced genetic engineering techniques, including transformation and genome editing tools like CRISPR/Cas9 enable molecular scientists to manipulate genes with remarkable precision and efficiency. CRISPR enables the simultaneous targeted editing of multiple genes that control key traits in medicinal plants, allowing for the efficient and accurate development of ideal plant varieties. Researchers can employ appropriate research methodologies to design CRISPR/Cas9 systems for the targeted deletion of harmful genetic elements or the introduction of gain-of-function mutations, enabling precise genome editing in medicinal plants. This technology significantly accelerates the genetic improvement and germplasm innovation. This review explores global trends in this research by conducting a bibliometric analysis of Scopus data (2013–2025), focusing on publication output, average annual citations, international collaborations, keyword usage (via word clouds, co-occurrence networks, and overlay visualizations), and thematic evaluations. The analysis revealed a significant rise in directed mutagenesis vis-à-vis Crispr/Cas9 related studies in medicinal plants across countries, especially in China, USA and India. This review also explores the use of various gene editing approaches especially CRISPR/Cas9 technology and its future prospects to enhance the nutritive values and other characters of medicinal crops.