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<p>Systemic sclerosis represents a&#xa0;potentially life-threatening condition with underlying fibrosis of many organs. The onset of the associated skin sclerosis usually occurs distally and can progress proximally. A&#xa0;case of a&#xa0;55-year-old woman who presented with proximal isolated, symmetric lipoatrophy and anti-NOR90 antibodies is described. The differential diagnosis of lipodystrophy (LD) requires assessment of involved skin areas, screening for metabolic diseases, and drug history. With this patient, the subcutaneous injection of piritramide over 18&#xa0;months led to severe localized LD and mimicked a&#xa0;systemic condition due to its symmetric appearance.</p>

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Proximale Hautatrophie und positive NOR-90-Antikörper: atypische systemische Sklerodermie oder Lipodystrophie?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月13日

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  • Jan-Gerd Rademacher

摘要

Systemic sclerosis represents a potentially life-threatening condition with underlying fibrosis of many organs. The onset of the associated skin sclerosis usually occurs distally and can progress proximally. A case of a 55-year-old woman who presented with proximal isolated, symmetric lipoatrophy and anti-NOR90 antibodies is described. The differential diagnosis of lipodystrophy (LD) requires assessment of involved skin areas, screening for metabolic diseases, and drug history. With this patient, the subcutaneous injection of piritramide over 18 months led to severe localized LD and mimicked a systemic condition due to its symmetric appearance.