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<p>Dopamine, a critical neurotransmitter, plays a pivotal role in regulating various physiological and neurological processes. The detection and monitoring of dopamine levels are essential for understanding the pathophysiology of diseases such as Parkinson’s, Alzheimer’s, and depression. Reduced graphene oxide (rGO)-based electrochemical sensors have garnered significant attention due to their exceptional properties, including superior electrical conductivity, expansive surface area, and remarkable functionalization potential. This review article provides a comprehensive discussion of recent advancements over the past eight years in rGO-based dopamine electrochemical sensors, encompassing rGO synthesis techniques and surface modification methods. The integration of rGO with other materials, such as inorganic compounds, polymers, and biomolecules, is also examined to assess sensor performance metrics, including detection limit, sensitivity, and linear range. Finally, we elucidate future research prospects for the development of more effective rGO-based dopamine electrochemical sensors.</p> Graphical Abstract <p></p>

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Development of Electrochemical Dopamine Sensors Based on Reduced Graphene Oxide (rGO): Synthesis Strategies, Composite Materials, and Sensor Performance

  • 期刊论文

  • 发表日期：

    2026年3月2日

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  • M. Yasser,
  • Abdul Wahid Wahab,
  • Abdul Karim,
  • St. Fauziah,
  • Paulina Taba,
  • Syaharuddin Kasim,
  • Syarifuddin Liong,
  • Nasriadi Dali,
  • Abdur Rahman Arif,
  • Arini Rajab,
  • Anita Anita,
  • Fatimah Fatimah,
  • Rosalin Rosalin

摘要

Dopamine, a critical neurotransmitter, plays a pivotal role in regulating various physiological and neurological processes. The detection and monitoring of dopamine levels are essential for understanding the pathophysiology of diseases such as Parkinson’s, Alzheimer’s, and depression. Reduced graphene oxide (rGO)-based electrochemical sensors have garnered significant attention due to their exceptional properties, including superior electrical conductivity, expansive surface area, and remarkable functionalization potential. This review article provides a comprehensive discussion of recent advancements over the past eight years in rGO-based dopamine electrochemical sensors, encompassing rGO synthesis techniques and surface modification methods. The integration of rGO with other materials, such as inorganic compounds, polymers, and biomolecules, is also examined to assess sensor performance metrics, including detection limit, sensitivity, and linear range. Finally, we elucidate future research prospects for the development of more effective rGO-based dopamine electrochemical sensors.

Graphical Abstract