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<p>An innovative electrochemical dopamine sensor was fabricated by integrating zinc oxide nanoparticles and poly(cyanocobalamin) onto a screen-printed carbon electrode. Utilizing almond gum as a reducing agent, a sustainable synthesis method yielded crystalline ZnO nanoparticles under ambient conditions. The nanocomposite-modified electrode was thoroughly characterized using state-of-the-art spectroscopic and microscopic techniques. Voltammetric analysis demonstrated a linear correlation between dopamine concentrations (100–600 µM) and electrochemical response, exhibiting a sensitivity of 1.3725 µAµM⁻¹cm⁻² and a detection limit of 1.6047 µM. The sensor’s performance was confirmed through successful real-sample analysis, showcasing its potential for practical utility. Comparative evaluation with our existing electrodes underscored the benefits of this novel approach.</p> Graphical Abstract <p></p>

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Poly(cyanocobalamin)/ZnO Nanocomposite-Modified Screen-Printed Carbon Electrode: A Tool for Dopamine Detection

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • Suriya Devi Balasubramanian,
  • Karthikeyan Rajendran,
  • Anitha Mannarsamy,
  • Prakash Subash

摘要

An innovative electrochemical dopamine sensor was fabricated by integrating zinc oxide nanoparticles and poly(cyanocobalamin) onto a screen-printed carbon electrode. Utilizing almond gum as a reducing agent, a sustainable synthesis method yielded crystalline ZnO nanoparticles under ambient conditions. The nanocomposite-modified electrode was thoroughly characterized using state-of-the-art spectroscopic and microscopic techniques. Voltammetric analysis demonstrated a linear correlation between dopamine concentrations (100–600 µM) and electrochemical response, exhibiting a sensitivity of 1.3725 µAµM⁻¹cm⁻² and a detection limit of 1.6047 µM. The sensor’s performance was confirmed through successful real-sample analysis, showcasing its potential for practical utility. Comparative evaluation with our existing electrodes underscored the benefits of this novel approach.

Graphical Abstract