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<p>In the present work, a straightforward approach was adopted to synthesize concentration-dependent multiwall carbon nanotubes with silver-doped titanium oxide (Ag-TiO<sub>2</sub>) composites. The antibacterial activity was examined against Gram-positive and Gram-negative bacteria, increasing from 12.5 to 16.5&#xa0;mm for <i>S. aureus</i>, 20.5 to 26&#xa0;mm for <i>C. jejuni</i>, and 19.5 to 25.5&#xa0;mm for <i>V. cholerae</i>, incorporating 5% and 10% MWCNTs with Ag-TiO<sub>2</sub>, respectively. An Ag-TiO<sub>2</sub>-10% MWCNTs-GCE system was developed for the simultaneous detection of ascorbic acid (AA) and paracetamol (PA). Under optimal conditions, the sensor demonstrates linearity for AA (0.5–300&#xa0;µM) and PA (0.01–500&#xa0;µM) (<i>n</i> = 3), respectively. The corresponding detection limits for AA and PA were 0.038 and 0.008&#xa0;μM. This electrochemical sensor exhibits tremendous promise for a variety of medical applications, particularly in AA and PA monitoring, and offers a straightforward and extremely sensitive approach for detecting AA and PA in human serum samples and pharmaceutical samples.</p> Graphical Abstract <p></p>

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Influence of MWCNT Concentration on Antibacterial and Simultaneous Electrochemical Sensing of Ascorbic Acid and Paracetamol for Ag-Doped TiO2 Composites

  • 期刊论文

  • 发表日期：

    2025年8月16日

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  • Saima Rafique,
  • Adnan Shafique,
  • Farrukh Bashir Kayani,
  • Rizwan Akram,
  • Mozaffar Hussain,
  • Zobia Noreen,
  • Shazia Bashir

摘要

In the present work, a straightforward approach was adopted to synthesize concentration-dependent multiwall carbon nanotubes with silver-doped titanium oxide (Ag-TiO2) composites. The antibacterial activity was examined against Gram-positive and Gram-negative bacteria, increasing from 12.5 to 16.5 mm for S. aureus, 20.5 to 26 mm for C. jejuni, and 19.5 to 25.5 mm for V. cholerae, incorporating 5% and 10% MWCNTs with Ag-TiO2, respectively. An Ag-TiO2-10% MWCNTs-GCE system was developed for the simultaneous detection of ascorbic acid (AA) and paracetamol (PA). Under optimal conditions, the sensor demonstrates linearity for AA (0.5–300 µM) and PA (0.01–500 µM) (n = 3), respectively. The corresponding detection limits for AA and PA were 0.038 and 0.008 μM. This electrochemical sensor exhibits tremendous promise for a variety of medical applications, particularly in AA and PA monitoring, and offers a straightforward and extremely sensitive approach for detecting AA and PA in human serum samples and pharmaceutical samples.

Graphical Abstract