<p>Patients undergoing treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), such as aceclofenac (ACF), primarily aimed at managing conditions like rheumatoid arthritis, face potential risks associated with overdosage, impacting organs like the kidney, liver, gastrointestinal tract, and blood cells. Hence, accurate quantification of ACF in real samples becomes paramount. In this investigation, we propose an innovative voltammetric approach for the determination of ACF in urine specimens. The working electrode employed herein consisted of a glassy carbon electrode (GCE) modified with boron nitride quantum dots doped bismuth cerium oxide nanocomposite (Bi₂O₃/CeO₂@B-NQds/GCE). Comprehensive characterization of the Bi₂O₃/CeO₂@B-NQds/GCE was conducted utilizing various techniques, followed by photoelectrochemical (PEC) analysis. These photosensors exhibited commendable sensitivity and reproducibility, and their preparation was deemed facile, rapid, and cost-effective. The impact of diverse interfering species was scrutinized, alongside calibration procedures to ascertain analytical performance. Remarkably, the results unveiled a high degree of linearity within the range of 0.6 to 13.8&#xa0;µM, with exceptional values for the limit of detection 4.2&#xa0;nM. Moreover, the constructed photoelectrode demonstrated stability and reproducibility, showcasing promising potential for reliable ACF detection in urine samples upon successful validation. In addition to its potential for clinical diagnostics, this novel light-assisted voltammetric technique holds promise for enhancing patient care by enabling precise monitoring of ACF levels in urine, facilitating personalized treatment regimens for individuals undergoing NSAID therapy. Furthermore, its ease of use and cost-effectiveness make it a practical tool for routine screening in medical settings, offering a valuable asset for healthcare professionals striving to optimize patient outcomes.</p> Graphical Abstract <p></p>