Scholarlink

<p>Cervical cancer (CC) remains a major global health challenge, largely driven by persistent infection with high-risk human papillomavirus (HPV) genotypes. Emerging evidence suggests that the interplay between HPV, the vaginal microbiota (VM), and host immune responses critically influences viral persistence and disease progression. In particular, dysbiotic VM marked by reduced Lactobacillus dominance and increased prevalence of anaerobic bacteria such as <i>Gardnerella</i>, <i>Sneathia</i>, <i>Prevotella</i>, and <i>Atopobium</i>—can impair HPV clearance, promote chronic inflammation, and facilitate progression from cervical intraepithelial neoplasia (CIN) to invasive carcinoma. Understanding these tripartite interactions offers opportunities for novel preventive and therapeutic strategies, including microbiome modulation, immunotherapy, and gene editing. This review highlights the potential of microbiome-targeted interventions to enhance immune responses against HPV and reduce the burden of CC, although the underlying causal mechanisms require further investigation in prospective studies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The interplay between HPV, vaginal microbiota and host immunity in cervical carcinogenesis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月31日

查看全文
  • Nima Afshar Moghaddam,
  • Aria Mohabbat,
  • Maryam Pourdehghan Jigheh,
  • Ametis Mahboubi,
  • Zahra Zenderuh Ravanlo,
  • Dariush Shanehbandi,
  • Somayeh Shokri,
  • Hossein Bannazadeh Baghi

摘要

Cervical cancer (CC) remains a major global health challenge, largely driven by persistent infection with high-risk human papillomavirus (HPV) genotypes. Emerging evidence suggests that the interplay between HPV, the vaginal microbiota (VM), and host immune responses critically influences viral persistence and disease progression. In particular, dysbiotic VM marked by reduced Lactobacillus dominance and increased prevalence of anaerobic bacteria such as Gardnerella, Sneathia, Prevotella, and Atopobium—can impair HPV clearance, promote chronic inflammation, and facilitate progression from cervical intraepithelial neoplasia (CIN) to invasive carcinoma. Understanding these tripartite interactions offers opportunities for novel preventive and therapeutic strategies, including microbiome modulation, immunotherapy, and gene editing. This review highlights the potential of microbiome-targeted interventions to enhance immune responses against HPV and reduce the burden of CC, although the underlying causal mechanisms require further investigation in prospective studies.