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Background <p>Cutaneous metastases from primary malignant neoplasms are rare in clinical practice, especially in intrahepatic cholangiocarcinoma(ICC). ICC features highly invasive and metastatic biological behaviors, early extrahepatic metastasis. Distant lymph nodes are the most common metastatic site for ICC, followed by the lungs and bones, whereas Cutaneous metastasis is very rare, usually indicating a poor prognosis and low survival rate.</p> Case presentation <p>We present the case of a 69-year-old woman with cutaneous metastases from ICC who survived for four years. The patient underwent cutaneous metastatic tumor resection, chemotherapy, targeted therapy, and immune checkpoint inhibitors combined treatment, achieving long-term disease control. In this case, multidisciplinary treatment can delay the progression of the disease to a certain extent and improve the quality of life for the patient.</p> Conclusion <p>Cutaneous metastases from intrahepatic cholangiocarcinoma are exceedingly rare and therapeutic challenges. While treatment protocols lack standardization, combination therapy of surgical resection with ICI and targeted therapy shows promising efficacy in cutaneous metastases from ICC. Continued research and collaboration are essential to further refine therapeutic strategies, ultimately enhancing outcomes for patients with cutaneous metastases from ICC.</p>

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Cutaneous metastases from intrahepatic cholangiocarcinoma: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月2日

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  • Ying Zhang,
  • Yong Li,
  • Chao Liu,
  • Liqun Wu

摘要

Background

Cutaneous metastases from primary malignant neoplasms are rare in clinical practice, especially in intrahepatic cholangiocarcinoma(ICC). ICC features highly invasive and metastatic biological behaviors, early extrahepatic metastasis. Distant lymph nodes are the most common metastatic site for ICC, followed by the lungs and bones, whereas Cutaneous metastasis is very rare, usually indicating a poor prognosis and low survival rate.

Case presentation

We present the case of a 69-year-old woman with cutaneous metastases from ICC who survived for four years. The patient underwent cutaneous metastatic tumor resection, chemotherapy, targeted therapy, and immune checkpoint inhibitors combined treatment, achieving long-term disease control. In this case, multidisciplinary treatment can delay the progression of the disease to a certain extent and improve the quality of life for the patient.

Conclusion

Cutaneous metastases from intrahepatic cholangiocarcinoma are exceedingly rare and therapeutic challenges. While treatment protocols lack standardization, combination therapy of surgical resection with ICI and targeted therapy shows promising efficacy in cutaneous metastases from ICC. Continued research and collaboration are essential to further refine therapeutic strategies, ultimately enhancing outcomes for patients with cutaneous metastases from ICC.