Scholarlink

<p>Dysregulation of chromatin is considered one of the root causes of tumor occurrence and progression. In the past two decades, the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, a crucial player in chromatin remodeling, has emerged as a significant focus of cancer research and has been found to play a pivotal role in cancer development and progression through the regulation of the expression of cancer-related genes. Notably, studies have unveiled that genetic mutations and functional alterations in the SWI/SNF complex subunits, such as ARID1A, are prevalent across a broad spectrum of cancers, but the role of this complex in genitourinary neoplasms has not been systematically summarized yet. Therefore, in this review, we have summarized the mechanisms of SWI/SNF complex components in the occurrence and development of urological tumors. In addition, we have also discussed its clinical value and presented treatment strategies that target the SWI/SNF complex in order to provide a comprehensive overview of the status of current research and future areas of clinical focus in this field.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Implications for clinical prognosis and target discovery of the SWI/SNF complex in genitourinary tumors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月12日

查看全文
  • Zheng Tang,
  • Haodong Chi,
  • Weiguang Zhao,
  • Renjie Wang,
  • Yin Yang,
  • Zijie Xu,
  • Zetao Ding,
  • Kaiying Chen,
  • Junru Lu,
  • Sang Hu,
  • Zhixian Yao,
  • Zhihong Liu

摘要

Dysregulation of chromatin is considered one of the root causes of tumor occurrence and progression. In the past two decades, the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, a crucial player in chromatin remodeling, has emerged as a significant focus of cancer research and has been found to play a pivotal role in cancer development and progression through the regulation of the expression of cancer-related genes. Notably, studies have unveiled that genetic mutations and functional alterations in the SWI/SNF complex subunits, such as ARID1A, are prevalent across a broad spectrum of cancers, but the role of this complex in genitourinary neoplasms has not been systematically summarized yet. Therefore, in this review, we have summarized the mechanisms of SWI/SNF complex components in the occurrence and development of urological tumors. In addition, we have also discussed its clinical value and presented treatment strategies that target the SWI/SNF complex in order to provide a comprehensive overview of the status of current research and future areas of clinical focus in this field.