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Background <p>Photodynamic therapy (PDT) has emerged as a promising minimally invasive strategy for breast cancer, leveraging photosensitizing agents, light activation, and oxygen to generate cytotoxic effects. This bibliometric analysis explores the knowledge structure, evolutionary trends, and research frontiers within the PDT domain for breast cancer from 2000 to 2025.</p> Methods <p>Data were retrieved from the Web of Science Core Collection and PubMed (2000–2025). A total of 3,785 publications were analyzed using Bibliometrix, VOSviewer, and CiteSpace for co-authorship, co-citation, keyword co-occurrence, and burst detection analyses.</p> Results <p>Annual publications grew markedly, peaking in 2025. China led in productivity and citations, while the Chinese Academy of Sciences showed the highest betweenness centrality. Biomaterials was the most influential journal, and author collaboration networks revealed limited connectivity among core researchers. Keyword evolution identified three phases: basic exploration (2000–2017), technical development (2013–2021), and the current precision immunomodulation era (2020–present), with “tumor microenvironment” and “immunogenic cell death” as dominant contemporary themes.</p> Conclusion <p>This study delineates the intellectual landscape and shifting paradigms in breast cancer PDT research, underscoring a transition toward immune-focused and tumor-microenvironment–modulating strategies. Future efforts should prioritize interdisciplinary collaboration and PDT–immunotherapy combinations to advance clinical translation.</p>

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Bibliometric analysis reveals the current status and future trends of cancer associated photodynamic therapy in breast cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月10日

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  • Jinxiu Xie,
  • Siying Chen,
  • Shaoyu Fu,
  • Jiayi Rao,
  • Chenxi Wang,
  • Yan Xiao,
  • Kang Zou

摘要

Background

Photodynamic therapy (PDT) has emerged as a promising minimally invasive strategy for breast cancer, leveraging photosensitizing agents, light activation, and oxygen to generate cytotoxic effects. This bibliometric analysis explores the knowledge structure, evolutionary trends, and research frontiers within the PDT domain for breast cancer from 2000 to 2025.

Methods

Data were retrieved from the Web of Science Core Collection and PubMed (2000–2025). A total of 3,785 publications were analyzed using Bibliometrix, VOSviewer, and CiteSpace for co-authorship, co-citation, keyword co-occurrence, and burst detection analyses.

Results

Annual publications grew markedly, peaking in 2025. China led in productivity and citations, while the Chinese Academy of Sciences showed the highest betweenness centrality. Biomaterials was the most influential journal, and author collaboration networks revealed limited connectivity among core researchers. Keyword evolution identified three phases: basic exploration (2000–2017), technical development (2013–2021), and the current precision immunomodulation era (2020–present), with “tumor microenvironment” and “immunogenic cell death” as dominant contemporary themes.

Conclusion

This study delineates the intellectual landscape and shifting paradigms in breast cancer PDT research, underscoring a transition toward immune-focused and tumor-microenvironment–modulating strategies. Future efforts should prioritize interdisciplinary collaboration and PDT–immunotherapy combinations to advance clinical translation.