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Background <p>Colorectal cancer (CRC) is a digestive tract tumor and ranks as the third most common malignant tumor globally.</p> Purpose <p>This study aimed to confirm the effects of miR-3928/<i>IQGAP3</i> on the development and prognosis of CRC.</p> Methods <p>We assessed the prognostic value of miR-3928 through survival analyses using Kaplan-Meier plots and Cox regression modeling. The interaction between miR-3928 and <i>IQGAP3</i> was confirmed by RT-qPCR and Dual-Luciferase assay. We used CCK8, Transwell assay, and colony formation assay to examine their effects on SW480 and HT29 cell proliferation and migration.</p> Results <p>Low miR-3928 expression correlates with poor prognosis in CRC patients, while <i>IQGAP3</i> is highly expressed in CRC. MiR-3928 targets and regulates <i>IQGAP3</i>. Overexpression of miR-3928 inhibits the proliferation and migration of CRC cells, but overexpression of <i>IQGAP3</i> reverses this effect. Additionally, miR-3928 overexpression promotes ferroptosis, which may be a key mechanism underlying its ability to inhibit CRC cell proliferation.</p> Conclusion <p>In CRC, low miR-3928 expression correlates with poor prognosis. MiR-3928 suppresses CRC cell proliferation and migration by targeting <i>IQGAP3</i>, possibly through ferroptosis promotion. This study confirms that miR-3928 acts as a tumor suppressor in CRC, offering a potential target for prognostic evaluation.</p>

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MiR-3928 functions as a tumor suppressor and prognostic factor in colorectal cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月1日

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  • Yong Huang,
  • Yanfang Li,
  • Bin Zuo,
  • Riwei Wang

摘要

Background

Colorectal cancer (CRC) is a digestive tract tumor and ranks as the third most common malignant tumor globally.

Purpose

This study aimed to confirm the effects of miR-3928/IQGAP3 on the development and prognosis of CRC.

Methods

We assessed the prognostic value of miR-3928 through survival analyses using Kaplan-Meier plots and Cox regression modeling. The interaction between miR-3928 and IQGAP3 was confirmed by RT-qPCR and Dual-Luciferase assay. We used CCK8, Transwell assay, and colony formation assay to examine their effects on SW480 and HT29 cell proliferation and migration.

Results

Low miR-3928 expression correlates with poor prognosis in CRC patients, while IQGAP3 is highly expressed in CRC. MiR-3928 targets and regulates IQGAP3. Overexpression of miR-3928 inhibits the proliferation and migration of CRC cells, but overexpression of IQGAP3 reverses this effect. Additionally, miR-3928 overexpression promotes ferroptosis, which may be a key mechanism underlying its ability to inhibit CRC cell proliferation.

Conclusion

In CRC, low miR-3928 expression correlates with poor prognosis. MiR-3928 suppresses CRC cell proliferation and migration by targeting IQGAP3, possibly through ferroptosis promotion. This study confirms that miR-3928 acts as a tumor suppressor in CRC, offering a potential target for prognostic evaluation.