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Introduction <p>Skene’s gland adenocarcinoma is a rare female urethral neoplasm, there is no consensus regarding their treatment.</p> Case presentation <p>A 71&#xa0;year-old patient complained frequency of urination increased, and the aggravation was accompanied with dysuria for more than 1&#xa0;month. She underwent cystoscopy for stone removal and electrosurgery for bladder neck tumor. We describe the cystoscopic imaging, histologic, immunohistochemical, and clinical findings of the patient with Skene’s gland adenocarcinoma.</p> Management <p>The patient underwent robot-assisted cystectomy with Bricker ileal conduit formation and regional lymph node dissection under general anesthesia. Postoperative stage pT3aN1, with no radiotherapy or chemotherapy after surgery.</p> Follow-up <p>After 48&#xa0;months of follow-up, the patient is currently in good condition with a cystostomy.</p> Conclusion <p>We encourage physicians to take advantage of extensive knowledge and expanding tools in prostate cancer to manage Skene’s gland adenocarcinoma patients.</p>

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Skene’s gland adenocarcinoma: a case report and review of the literature

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  • 发表日期：

    2026年3月16日

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  • Jingping Wang,
  • Jie Zhou

摘要

Introduction

Skene’s gland adenocarcinoma is a rare female urethral neoplasm, there is no consensus regarding their treatment.

Case presentation

A 71 year-old patient complained frequency of urination increased, and the aggravation was accompanied with dysuria for more than 1 month. She underwent cystoscopy for stone removal and electrosurgery for bladder neck tumor. We describe the cystoscopic imaging, histologic, immunohistochemical, and clinical findings of the patient with Skene’s gland adenocarcinoma.

Management

The patient underwent robot-assisted cystectomy with Bricker ileal conduit formation and regional lymph node dissection under general anesthesia. Postoperative stage pT3aN1, with no radiotherapy or chemotherapy after surgery.

Follow-up

After 48 months of follow-up, the patient is currently in good condition with a cystostomy.

Conclusion

We encourage physicians to take advantage of extensive knowledge and expanding tools in prostate cancer to manage Skene’s gland adenocarcinoma patients.