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<p>Iron-dependent programmed cell death (known as ferroptosis) is closely linked to cervical cancer progression. Here, the present research identified that novel N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) writer methyltransferase-like 16 (METTL16) was a ferroptosis-related gene in cervical cancer, and more exploration was performed to investigate its function and mechanism. Results showed that METTL16 was elevated in the cervical cancer cells, and METTL16 functionally repressed the ferroptosis-related characteristic. Mechanistically, ferritin heavy chain 1 (FTH1) was identified as a direct target of METTL16 via the m<sup>6</sup>A-dependent manner. In <i>vivo</i>, METTL16 silencing repressed the cervical cancer tumor growth. Therefore, these findings revealed that novel m<sup>6</sup>A writer METTL16 promoted the cervical cancer tumorigenesis by targeting FTH1-dependent ferroptosis, which providing distinct insights for cervical cancer.</p>

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Novel N6-methyladenosine (m6A) writer METTL16 promotes the cervical cancer tumorigenesis by targeting FTH1-dependent ferroptosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月20日

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  • Zhisheng Huang,
  • Youzhen Luo,
  • Qiaoling Gao,
  • Lulu Wang,
  • Caihong Li

摘要

Iron-dependent programmed cell death (known as ferroptosis) is closely linked to cervical cancer progression. Here, the present research identified that novel N6-methyladenosine (m6A) writer methyltransferase-like 16 (METTL16) was a ferroptosis-related gene in cervical cancer, and more exploration was performed to investigate its function and mechanism. Results showed that METTL16 was elevated in the cervical cancer cells, and METTL16 functionally repressed the ferroptosis-related characteristic. Mechanistically, ferritin heavy chain 1 (FTH1) was identified as a direct target of METTL16 via the m6A-dependent manner. In vivo, METTL16 silencing repressed the cervical cancer tumor growth. Therefore, these findings revealed that novel m6A writer METTL16 promoted the cervical cancer tumorigenesis by targeting FTH1-dependent ferroptosis, which providing distinct insights for cervical cancer.