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Background <p>Cuproptosis, or copper-induced programmed cell death, shows promise in cancer therapy. However, the role of the copper-related gene dihydrofatty acyl dehydrogenase (DLD) in the prognosis of renal clear cell carcinoma (KIRC) remains unclear.</p> Methods <p>Raw data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed using R. DLD expression in cancer was evaluated through these databases, and its correlation with tumor immunological features was assessed using the TIMER and TISIDB databases.</p> Result <p>The results demonstrated that DLD is downregulated in KIRC, providing diagnostic and prognostic value. Cox regression identified DLD expression as a protective factor. GO and KEGG analyses revealed DLD-associated gene pathways, while its expression correlated with immune cell infiltration and marker expression in KIRC.</p> Conclusion <p>Our findings highlight DLD’s predictive value in KIRC and its role in the tumor microenvironment. As a diagnostic and prognostic marker, DLD offers potential for identifying therapeutic targets and enhancing KIRC immunotherapy.</p>

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Cuproptosis-related gene DLD expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月22日

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  • Cheng Qian,
  • Hu He,
  • Ganhua You

摘要

Background

Cuproptosis, or copper-induced programmed cell death, shows promise in cancer therapy. However, the role of the copper-related gene dihydrofatty acyl dehydrogenase (DLD) in the prognosis of renal clear cell carcinoma (KIRC) remains unclear.

Methods

Raw data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed using R. DLD expression in cancer was evaluated through these databases, and its correlation with tumor immunological features was assessed using the TIMER and TISIDB databases.

Result

The results demonstrated that DLD is downregulated in KIRC, providing diagnostic and prognostic value. Cox regression identified DLD expression as a protective factor. GO and KEGG analyses revealed DLD-associated gene pathways, while its expression correlated with immune cell infiltration and marker expression in KIRC.

Conclusion

Our findings highlight DLD’s predictive value in KIRC and its role in the tumor microenvironment. As a diagnostic and prognostic marker, DLD offers potential for identifying therapeutic targets and enhancing KIRC immunotherapy.