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Background <p>It is challenging to diagnose hepatic cirrhosis and hepatocellular carcinoma (HCC) at an early stage since non-invasive markers are not specific and do not identify the early stage.</p> Objective <p>Serum microRNA-192 could represent an early and critical pathogenetic factor in different liver diseases.</p> Methods <p>92 participants were allocated into four equal groups (<i>n</i> = 23): control, compensated liver cirrhosis, decompensated cirrhosis, and HCC groups.</p> Results <p>Decompensated cirrhosis and HCC showed significantly elevated Serum Alanine aminotransferase, aspartate aminotransferase, bilirubin, alpha-fetoprotein, and microRNA-192.</p> Conclusion <p>Serum microRNA-192 can predict decompensated liver cirrhosis and HCC with high sensitivity and specificity.</p>

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Assessment circulating micro-RNA-192 in Egyptian patients with non-viral liver cirrhosis and hepatocellular carcinoma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月23日

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  • Mohamed Abdelaleim Abdelaziz,
  • Abdallah Mohammed Elagali,
  • Ayman S. Soliman,
  • Hader I. Sakr,
  • Ahmed A. Ibrahim,
  • Alaa H. Huzien,
  • Jakleen Z. Abujamai,
  • Ahmed A. Damanhory,
  • Safy S. Gaber

摘要

Background

It is challenging to diagnose hepatic cirrhosis and hepatocellular carcinoma (HCC) at an early stage since non-invasive markers are not specific and do not identify the early stage.

Objective

Serum microRNA-192 could represent an early and critical pathogenetic factor in different liver diseases.

Methods

92 participants were allocated into four equal groups (n = 23): control, compensated liver cirrhosis, decompensated cirrhosis, and HCC groups.

Results

Decompensated cirrhosis and HCC showed significantly elevated Serum Alanine aminotransferase, aspartate aminotransferase, bilirubin, alpha-fetoprotein, and microRNA-192.

Conclusion

Serum microRNA-192 can predict decompensated liver cirrhosis and HCC with high sensitivity and specificity.