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Objective <p>Laryngeal squamous cell carcinoma (LSCC) remains a malignancy with rising incidence and poor prognosis. Understanding the molecular biomarkers is critical for improving diagnostic and therapeutic strategies. In this study, the expression levels of serum/glucocorticoid-regulated kinase 1 (SGK1) and the novel long non-coding RNA (lncRNA) Desmoglein-2 Antisense RNA 1 (DSG2-AS1) were assessed in LSCC tissues compared to adjacent normal tissues.</p> Methods <p>The gene and protein expression levels were assessed in the LSCC tissues (<i>n</i> = 50) compared to adjacent normal tissues (<i>n</i> = 50) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) technique and western blot analysis, respectively.</p> Results <p>Results showed that the SGK1 gene and protein expression levels (<i>p</i> = 0.015 and <i>p</i> &lt; 0.0001, respectively) and lncRNA DSG2-AS1 (<i>p</i> = 0.003) were elevated in cancerous tissues relative to corresponding normal tissues. Notably, a positive correlation was identified between SGK1 and DSG2-AS1 gene expression levels (<i>r</i> = 0.321, <i>p</i> = 0.001).</p> Conclusion <p>This study is the first to demonstrate concurrent upregulation of SGK1 and DSG2-AS1 in LSCC, as oncogene targets. It showed a potential relationship that may be involved in tumor progression among LSCC patients.</p>

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The oncogenic role of lncRNA DSG2-AS1 and its functional link to SGK1 in laryngeal squamous cell carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月5日

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  • Najmeh Parvaz,
  • Payam Mohammadi,
  • Maryam Lotfi,
  • Seyed Parsa Seyedi Taji,
  • Mohammad Shabani,
  • Mohammad Najafi

摘要

Objective

Laryngeal squamous cell carcinoma (LSCC) remains a malignancy with rising incidence and poor prognosis. Understanding the molecular biomarkers is critical for improving diagnostic and therapeutic strategies. In this study, the expression levels of serum/glucocorticoid-regulated kinase 1 (SGK1) and the novel long non-coding RNA (lncRNA) Desmoglein-2 Antisense RNA 1 (DSG2-AS1) were assessed in LSCC tissues compared to adjacent normal tissues.

Methods

The gene and protein expression levels were assessed in the LSCC tissues (n = 50) compared to adjacent normal tissues (n = 50) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) technique and western blot analysis, respectively.

Results

Results showed that the SGK1 gene and protein expression levels (p = 0.015 and p < 0.0001, respectively) and lncRNA DSG2-AS1 (p = 0.003) were elevated in cancerous tissues relative to corresponding normal tissues. Notably, a positive correlation was identified between SGK1 and DSG2-AS1 gene expression levels (r = 0.321, p = 0.001).

Conclusion

This study is the first to demonstrate concurrent upregulation of SGK1 and DSG2-AS1 in LSCC, as oncogene targets. It showed a potential relationship that may be involved in tumor progression among LSCC patients.