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<p>Bladder cancer is a malignant tumor ranks among the most common urogenital malignancies. Treatment efficacy specifically in MIBC remains suboptimal due to profound tumor heterogeneity. Gene and protein biomarkers provide the opportunity for precise diagnosis and treatment. In this study, by using bioinformatic portals, we identified DCUN1D5 as an upregulated gene that may influence pan-cancer prognosis. Its expression showed significant differences across histological grades and tumor subtypes in BLCA. We found that co-expression genes of DCUN1D5 were enriched in translation initiation factor activity and methyltransferase activity, suggesting potential regulatory mechanisms of DCUN1D5. Furthermore, we validated the prognostic role of DCUN1D5 in BLCA through immunohistochemical analysis of 56 tissue microarray samples. The relationship between DCUN1D5 expression and clinicopathological parameters of BLCA was analyzed by Chi-square test, and result was consistent with bioinformatic analysis. In conclusion, we identified DCUN1D5 as a novel potential Biomarker for predicting the prognosis of BLCA.</p>

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DCUN1D5 is a novel potential biomarker for predicting the prognosis of bladder cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月20日

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  • Xiaomin Han,
  • Lanqi Li,
  • Yuzhe Jia,
  • Lijuan Ai,
  • Xingyu Wang,
  • Chen Xu,
  • Rui Guo,
  • Rihan Wu,
  • Yilin Dong,
  • Shouyu Fang,
  • Ruixue Li,
  • Jiaming Zhang,
  • Jiaxin Luo,
  • Ziqi Zhou,
  • Yiju Wei,
  • Li Yang,
  • Hongge Ju,
  • Qiang Ma,
  • Kewen Zheng

摘要

Bladder cancer is a malignant tumor ranks among the most common urogenital malignancies. Treatment efficacy specifically in MIBC remains suboptimal due to profound tumor heterogeneity. Gene and protein biomarkers provide the opportunity for precise diagnosis and treatment. In this study, by using bioinformatic portals, we identified DCUN1D5 as an upregulated gene that may influence pan-cancer prognosis. Its expression showed significant differences across histological grades and tumor subtypes in BLCA. We found that co-expression genes of DCUN1D5 were enriched in translation initiation factor activity and methyltransferase activity, suggesting potential regulatory mechanisms of DCUN1D5. Furthermore, we validated the prognostic role of DCUN1D5 in BLCA through immunohistochemical analysis of 56 tissue microarray samples. The relationship between DCUN1D5 expression and clinicopathological parameters of BLCA was analyzed by Chi-square test, and result was consistent with bioinformatic analysis. In conclusion, we identified DCUN1D5 as a novel potential Biomarker for predicting the prognosis of BLCA.