Scholarlink

Background <p>Pharmaceuticals and Personal Care Products (PPCPs) are an emerging class of micropollutants that have attracted increasing attention in recent years. However, their potential role in prostate cancer (PCa) remains largely unexplored. This study aims to elucidate the mechanisms by which PPCPs influence PCa progression and identify key genes involved in this process.</p> Methods <p>A network toxicology approach was employed to identify PPCPs related genes associated with PCa. Bioinformatics analyses were conducted to pinpoint key genes and their underlying mechanisms. Additionally, molecular docking was performed to assess the binding affinity between PPCPs and the identified genes.</p> Results <p>The study analyzed the relationship between 49 types of PPCPs and PCa, ultimately identifying 24 types of PPCPs that may promote the development of PCa. Network toxicology analysis identified 156 PPCPs-PCa related genes. Further screening using univariate Cox regression analysis, clinical correlation analysis, and Lasso prognostic modeling revealed four prognostic genes closely linked to PCa outcomes. Molecular docking demonstrated strong binding affinities between these genes and the 24 PPCPs, with <i>SRD5A2</i> exhibiting the highest binding affinity. Moreover, immune infiltration analysis indicated a significant correlation between <i>SRD5A2</i> and the tumor immune microenvironment (TIME).</p> Conclusion <p>The genes <i>F2</i>, <i>SRD5A2</i>, <i>NEK2</i>, and <i>HGFAC</i> play critical roles in PPCPs induced PCa progression, with <i>SRD5A2</i> being particularly significant. These findings suggest that PPCPs may disrupt TIME homeostasis by downregulating <i>SRD5A2</i> expression, thereby promoting immune evasion of PCa cells and accelerating tumor progression.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Integrative analysis reveals SRD5A2 as a central mediator in PPCPs induced modulation of the prostate cancer immune microenvironment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月21日

查看全文
  • Tao Zhou,
  • Yuqi Li,
  • Peng Ji,
  • Chunyang Meng,
  • Zhiyu Liu,
  • Zhiqiang Zeng,
  • Yuming Yang,
  • Tao Li

摘要

Background

Pharmaceuticals and Personal Care Products (PPCPs) are an emerging class of micropollutants that have attracted increasing attention in recent years. However, their potential role in prostate cancer (PCa) remains largely unexplored. This study aims to elucidate the mechanisms by which PPCPs influence PCa progression and identify key genes involved in this process.

Methods

A network toxicology approach was employed to identify PPCPs related genes associated with PCa. Bioinformatics analyses were conducted to pinpoint key genes and their underlying mechanisms. Additionally, molecular docking was performed to assess the binding affinity between PPCPs and the identified genes.

Results

The study analyzed the relationship between 49 types of PPCPs and PCa, ultimately identifying 24 types of PPCPs that may promote the development of PCa. Network toxicology analysis identified 156 PPCPs-PCa related genes. Further screening using univariate Cox regression analysis, clinical correlation analysis, and Lasso prognostic modeling revealed four prognostic genes closely linked to PCa outcomes. Molecular docking demonstrated strong binding affinities between these genes and the 24 PPCPs, with SRD5A2 exhibiting the highest binding affinity. Moreover, immune infiltration analysis indicated a significant correlation between SRD5A2 and the tumor immune microenvironment (TIME).

Conclusion

The genes F2, SRD5A2, NEK2, and HGFAC play critical roles in PPCPs induced PCa progression, with SRD5A2 being particularly significant. These findings suggest that PPCPs may disrupt TIME homeostasis by downregulating SRD5A2 expression, thereby promoting immune evasion of PCa cells and accelerating tumor progression.

Graphical Abstract