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Objectives <p>VCP/p97 inhibition is known to upregulate PD-L1. This study investigated the correlation between PD-L1 and VCP/p97 expression in OPSCC, as well as the expression and prognostic significance of VCP/p97 in OPSCC.</p> Methods <p>The study retrospectively included 56 patients with OPSCC. Immunohistochemical staining was performed to detect VCP/p97 and PD-L1 expression. The staining intensity of VCP/p97 and PD-L1 TPS and CPS was determined. HPV status was evaluated using immunohistochemical staining against p16 and HPV PCR. In addition, iTILs were assessed.</p> Results <p>High VCP/p97 expression was observed in 67.9% of the tumors. A significant association was found between high VCP/p97 expression and low PD-L1 TPS (<i>p</i> = 0.025) and between high VCP/p97 and low iTILs (<i>p</i> = 0.015). No significant correlation was found between VCP/p97 and PD-L1 CPS. VCP/p97 showed no prognostic significance in OPSCC.</p> Conclusion <p>VCP/p97 is frequently overexpressed in OPSCC. The significant association of high VCP/p97 expression with low PD-L1 TPS and reduced iTILs could indicate that VCP/p97 inhibitor therapy may enhance the efficacy of PD-1 checkpoint inhibitor therapy in OPSCC.</p>

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High VCP/p97 expression associates with low PD-L1 TPS in oropharyngeal squamous cell carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月20日

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  • Inga Marte Charlott Seuthe,
  • Markus Ruwe,
  • Franz Mitze,
  • Steffi Silling,
  • Eric Ehrke-Schulz,
  • Sabine Eichhorn,
  • Jonas Jae-Hyun Park

摘要

Objectives

VCP/p97 inhibition is known to upregulate PD-L1. This study investigated the correlation between PD-L1 and VCP/p97 expression in OPSCC, as well as the expression and prognostic significance of VCP/p97 in OPSCC.

Methods

The study retrospectively included 56 patients with OPSCC. Immunohistochemical staining was performed to detect VCP/p97 and PD-L1 expression. The staining intensity of VCP/p97 and PD-L1 TPS and CPS was determined. HPV status was evaluated using immunohistochemical staining against p16 and HPV PCR. In addition, iTILs were assessed.

Results

High VCP/p97 expression was observed in 67.9% of the tumors. A significant association was found between high VCP/p97 expression and low PD-L1 TPS (p = 0.025) and between high VCP/p97 and low iTILs (p = 0.015). No significant correlation was found between VCP/p97 and PD-L1 CPS. VCP/p97 showed no prognostic significance in OPSCC.

Conclusion

VCP/p97 is frequently overexpressed in OPSCC. The significant association of high VCP/p97 expression with low PD-L1 TPS and reduced iTILs could indicate that VCP/p97 inhibitor therapy may enhance the efficacy of PD-1 checkpoint inhibitor therapy in OPSCC.