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<p>Amine oxidase copper containing 3 (<i>AOC3</i>) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function. However, the potential function of <i>AOC3</i> in cancer had not been fully studied. We conducted a comprehensive analysis of the potential function of <i>AOC3</i> in pan-cancer using multiple online databases and analytical methods, including mutations and differential expression analysis, pathway analysis and immune analysis. Then, the function of the <i>AOC3</i> was assessed in colorectal cancer (CRC) cells. Pan-cancer analysis results show that the highest mutation frequency of <i>ACO3</i> in embryonic tumor patients, in most cancers, the expression of <i>AOC3</i> is significantly downregulated and the differential expression of <i>AOC3</i> was mainly concentrated in CRC and female tumors. Enrichment analysis showed that <i>AOC3</i> was involved in PPAR signaling pathway. In addition, bioinformatic investigation revealed a link between the <i>AOC3</i> with immune cell infiltration in the tumor microenvironment. Cell experiments have confirmed that <i>AOC3</i> can significantly regulate the apoptosis and cycle progression of CRC cells. In summary, our study not only comprehensively analyzed the potential mechanisms of <i>AOC3</i> in pan-cancer, but also validated the potential regulatory role of <i>AOC3</i> through CRC cell experiments.</p>

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Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Guanlong Wang,
  • Lidan Zhu,
  • Ling Lu,
  • Guangyang Wu,
  • Bangjie Wang,
  • Changjun Yu

摘要

Amine oxidase copper containing 3 (AOC3) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function. However, the potential function of AOC3 in cancer had not been fully studied. We conducted a comprehensive analysis of the potential function of AOC3 in pan-cancer using multiple online databases and analytical methods, including mutations and differential expression analysis, pathway analysis and immune analysis. Then, the function of the AOC3 was assessed in colorectal cancer (CRC) cells. Pan-cancer analysis results show that the highest mutation frequency of ACO3 in embryonic tumor patients, in most cancers, the expression of AOC3 is significantly downregulated and the differential expression of AOC3 was mainly concentrated in CRC and female tumors. Enrichment analysis showed that AOC3 was involved in PPAR signaling pathway. In addition, bioinformatic investigation revealed a link between the AOC3 with immune cell infiltration in the tumor microenvironment. Cell experiments have confirmed that AOC3 can significantly regulate the apoptosis and cycle progression of CRC cells. In summary, our study not only comprehensively analyzed the potential mechanisms of AOC3 in pan-cancer, but also validated the potential regulatory role of AOC3 through CRC cell experiments.